Uptake of magnesium and calcium by mitochondria in exchange for hydrogen ions

J. D. Judah; K. Ahmed; A. E.M. McLean; G. S. Christie

doi:10.1016/0926-6585(65)90053-1

Uptake of magnesium and calcium by mitochondria in exchange for hydrogen ions

J. D. Judah, K. Ahmed, A. E.M. McLean, G. S. Christie

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

1. 1. Rat-liver mitochondria take up Mg²⁺ in exchange for H⁺. 2. 2. Inorganic orthophosphate is not essential for Mg²⁺ uptake. 3. 3. Inorganic orthophosphate uptake can take place in the absence of Mg²⁺. 4. 4. Rat-liver mitochondria take up Ca²⁺, in part at least, by the same route as Mg²⁺. H⁺ is exchanged for Ca²⁺. 5. 5. The divalent cations appear to share a common transport mechanism with K⁺. 6. 6. It is concluded that mitochondrial cation-transport mechanism is a system which extrudes H⁺. Any one of several cations may be taken up in exchange. 7. 7. An explanation is advanced for the opposing effects of 2,4-dinitrophenol and Ca²⁺ on mitochondrial swelling. 8. 8. The sensitivity and specificity of atomic absorption spectrophometry facilitated analysis of Ca²⁺ and Mg²⁺.

Original language	English (US)
Pages (from-to)	452-460
Number of pages	9
Journal	BBA - Biophysics Including Photosynthesis
Volume	94
Issue number	2
DOIs	https://doi.org/10.1016/0926-6585(65)90053-1
State	Published - Mar 29 1965

Bibliographical note

Funding Information:
We are indebted to Miss S. ELSEY and Mr. W. GARRETT for skilled technical assistance. This work was supported by grants from the U.S. Public Health Service (AM 7226-02); the Life Insurance Medical Research Fund, the Otho S.A. Sprague Memorial hlstitute and the Burroughs-Wellcome Fund. G. S. C. was in receipt of a travel grant from the Anti Cancer Council, Victoria, Australia. A. E.M. McL. was in receipt of a U.S. Public Health Service International Fellowship (No. FF 492).

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title = "Uptake of magnesium and calcium by mitochondria in exchange for hydrogen ions",

abstract = "1. 1. Rat-liver mitochondria take up Mg2+ in exchange for H+. 2. 2. Inorganic orthophosphate is not essential for Mg2+ uptake. 3. 3. Inorganic orthophosphate uptake can take place in the absence of Mg2+. 4. 4. Rat-liver mitochondria take up Ca2+, in part at least, by the same route as Mg2+. H+ is exchanged for Ca2+. 5. 5. The divalent cations appear to share a common transport mechanism with K+. 6. 6. It is concluded that mitochondrial cation-transport mechanism is a system which extrudes H+. Any one of several cations may be taken up in exchange. 7. 7. An explanation is advanced for the opposing effects of 2,4-dinitrophenol and Ca2+ on mitochondrial swelling. 8. 8. The sensitivity and specificity of atomic absorption spectrophometry facilitated analysis of Ca2+ and Mg2+.",

author = "Judah, {J. D.} and K. Ahmed and McLean, {A. E.M.} and Christie, {G. S.}",

note = "Funding Information: We are indebted to Miss S. ELSEY and Mr. W. GARRETT for skilled technical assistance. This work was supported by grants from the U.S. Public Health Service (AM 7226-02); the Life Insurance Medical Research Fund, the Otho S.A. Sprague Memorial hlstitute and the Burroughs-Wellcome Fund. G. S. C. was in receipt of a travel grant from the Anti Cancer Council, Victoria, Australia. A. E.M. McL. was in receipt of a U.S. Public Health Service International Fellowship (No. FF 492).",

year = "1965",

month = mar,

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doi = "10.1016/0926-6585(65)90053-1",

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AU - Judah, J. D.

AU - Ahmed, K.

AU - McLean, A. E.M.

AU - Christie, G. S.

N1 - Funding Information: We are indebted to Miss S. ELSEY and Mr. W. GARRETT for skilled technical assistance. This work was supported by grants from the U.S. Public Health Service (AM 7226-02); the Life Insurance Medical Research Fund, the Otho S.A. Sprague Memorial hlstitute and the Burroughs-Wellcome Fund. G. S. C. was in receipt of a travel grant from the Anti Cancer Council, Victoria, Australia. A. E.M. McL. was in receipt of a U.S. Public Health Service International Fellowship (No. FF 492).

PY - 1965/3/29

Y1 - 1965/3/29

N2 - 1. 1. Rat-liver mitochondria take up Mg2+ in exchange for H+. 2. 2. Inorganic orthophosphate is not essential for Mg2+ uptake. 3. 3. Inorganic orthophosphate uptake can take place in the absence of Mg2+. 4. 4. Rat-liver mitochondria take up Ca2+, in part at least, by the same route as Mg2+. H+ is exchanged for Ca2+. 5. 5. The divalent cations appear to share a common transport mechanism with K+. 6. 6. It is concluded that mitochondrial cation-transport mechanism is a system which extrudes H+. Any one of several cations may be taken up in exchange. 7. 7. An explanation is advanced for the opposing effects of 2,4-dinitrophenol and Ca2+ on mitochondrial swelling. 8. 8. The sensitivity and specificity of atomic absorption spectrophometry facilitated analysis of Ca2+ and Mg2+.

AB - 1. 1. Rat-liver mitochondria take up Mg2+ in exchange for H+. 2. 2. Inorganic orthophosphate is not essential for Mg2+ uptake. 3. 3. Inorganic orthophosphate uptake can take place in the absence of Mg2+. 4. 4. Rat-liver mitochondria take up Ca2+, in part at least, by the same route as Mg2+. H+ is exchanged for Ca2+. 5. 5. The divalent cations appear to share a common transport mechanism with K+. 6. 6. It is concluded that mitochondrial cation-transport mechanism is a system which extrudes H+. Any one of several cations may be taken up in exchange. 7. 7. An explanation is advanced for the opposing effects of 2,4-dinitrophenol and Ca2+ on mitochondrial swelling. 8. 8. The sensitivity and specificity of atomic absorption spectrophometry facilitated analysis of Ca2+ and Mg2+.

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JO - BBA - Biophysics Including Photosynthesis

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Uptake of magnesium and calcium by mitochondria in exchange for hydrogen ions

Abstract

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