Update on transplanting beta cells for reversing type 1 diabetes

Paul Robertson

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Whole pancreas has been used successfully for transplantation for more than 30 years, and islets have been used reproducibly with success for 10 years; both procedures require drugs for immunosuppression. Success is judged by discontinuation of exogenous insulin-based treatment and maintenance of normal or nearly normal hemoglobin A1c. Successful pancreas transplantation has beneficial effects on retinopathy, nephropathy, neuropathy, macrovascular disease, and quality of life. Such findings are suggested for islet transplantation, but insufficient information is available to draw firm conclusions. Because of the paucity of annual pancreas donations, research for human beta cell surrogates is essential to provide a transplantation approach to therapy for a greater number of recipients.

Original languageEnglish (US)
Pages (from-to)655-667
Number of pages13
JournalEndocrinology and Metabolism Clinics of North America
Volume39
Issue number3
DOIs
StatePublished - Sep 1 2010

Keywords

  • Beta cells
  • Islet transplantation
  • Pancreas transplantation
  • Type 1 diabetes

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