Unusual benefits of macromolecular shielding by polyethylene glycol for reactions at the diffusional limit: The case of factor VIIai and tissue factor

Keyphrases

• Polyethylene Glycol 100%
• Tissue Factor 100%
• Diffusional 100%
• Loss Function 30%
• Macromolecules 20%
• Active Sites 20%
• Chemical Binding 20%
• Factor VIIa 20%
• Potential Impact 10%
• Protein Modification 10%
• Modified Proteins 10%
• Kinetic Mechanism 10%
• Low Protein 10%
• Anticoagulant Therapy 10%
• Antigenicity 10%
• High Loss 10%
• Protein Surface 10%
• Factor IXa 10%
• Good Target 10%
• Overall Properties 10%
• Higher Functions 10%
• Modified Parameters 10%
• Blood Clotting Factors 10%
• Factor Xa 10%
• Fold Increase 10%

Biochemistry, Genetics and Molecular Biology

• Ethylene 100%
• Thromboplastin 100%
• Lifespan 33%
• Macromolecule 22%
• Active Site 22%
• Facilitated Diffusion 22%
• Chemical Binding 22%
• Protein Modification 11%
• Wild Type 11%
• Anticoagulation 11%
• Antigenicity 11%
• Prothrombinase 11%

Pharmacology, Toxicology and Pharmaceutical Science

• Macrogol 100%
• Thromboplastin 100%
• Macrogol Derivative 90%
• Anticoagulation Therapy 10%
• Blood Clotting Factor 10a 10%
• Blood Clotting Factor 9a 10%