Untoward effects of fenfluramine in autistic children

George M. Realmuto, Jonathan Jensen, William Klykylo, Leonard Piggott, Gene Stubbs, Arthur Yuwiler, Edward Geller, B. J. Freeman, Edward Ritvo

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Several recent studies have described the benefits of fenfluramine for the symptomatic treatment of infantile autism. No large surveys of side effects of this drug have been reported in autistic children. To evaluate the untoward effects of fenfluramine in children with autism, 12 subjects were systematically studied. Medication was administered in a double-blind, placebo-controlled crossover study. Parents were trained in monitoring untoward effects. These observations were compiled in detailed daily notes. In addition, four cases describing unusual effects found in a sample of 170 patients treated with fenfluramine are also reported.

Original languageEnglish (US)
Pages (from-to)350-354
Number of pages5
JournalJournal of Clinical Psychopharmacology
Issue number6
StatePublished - Dec 1986


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