Unmasking cryptococcal meningitis immune reconstitution inflammatory syndrome in pregnancy induced by HIV antiretroviral therapy with postpartum paradoxical exacerbation

Reuben Kiggundu; Joshua Rhein; David B. Meya; David R. Boulware; Nathan C. Bahr

doi:10.1016/j.mmcr.2014.05.001

Unmasking cryptococcal meningitis immune reconstitution inflammatory syndrome in pregnancy induced by HIV antiretroviral therapy with postpartum paradoxical exacerbation

Reuben Kiggundu
, Joshua Rhein
, David B. Meya
, David R. Boulware
, Nathan C. Bahr

Medicine - Infectious Disease and International Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Cryptococcosis is the most common cause of meningitis in Africa due to the high burden of HIV. Immune reconstitution inflammatory syndrome (IRIS) is a frequent and deadly complication of cryptococcal meningitis. We report a fatal case of cryptococcal-IRIS in a pregnant woman that began after starting antiretroviral therapy (unmasking IRIS) and markedly worsened postpartum after delivery (paradoxical IRIS).

Original language	English (US)
Pages (from-to)	16-19
Number of pages	4
Journal	Medical Mycology Case Reports
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/j.mmcr.2014.05.001
State	Published - 2014

Bibliographical note

Funding Information:
The authors are supported by the National Institute of Neurologic Diseases and Stroke , the National Institute of Allergy and Infectious Diseases and Fogarty International Center ( R01NS086312-01 , R01AI078934-04 , R25TW009345-02 ). We thank Drs. Henry Nabeta and Abdu Musubire for patient care.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

AIDS
Cryptococcus meningitis
HIV
Immune reconstitution inflammatory syndrome
Postpartum
Pregnancy

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10.1016/j.mmcr.2014.05.001

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title = "Unmasking cryptococcal meningitis immune reconstitution inflammatory syndrome in pregnancy induced by HIV antiretroviral therapy with postpartum paradoxical exacerbation",

abstract = "Cryptococcosis is the most common cause of meningitis in Africa due to the high burden of HIV. Immune reconstitution inflammatory syndrome (IRIS) is a frequent and deadly complication of cryptococcal meningitis. We report a fatal case of cryptococcal-IRIS in a pregnant woman that began after starting antiretroviral therapy (unmasking IRIS) and markedly worsened postpartum after delivery (paradoxical IRIS).",

keywords = "AIDS, Cryptococcus meningitis, HIV, Immune reconstitution inflammatory syndrome, Postpartum, Pregnancy",

author = "Reuben Kiggundu and Joshua Rhein and Meya, \{David B.\} and Boulware, \{David R.\} and Bahr, \{Nathan C.\}",

note = "Funding Information: The authors are supported by the National Institute of Neurologic Diseases and Stroke , the National Institute of Allergy and Infectious Diseases and Fogarty International Center ( R01NS086312-01 , R01AI078934-04 , R25TW009345-02 ). We thank Drs. Henry Nabeta and Abdu Musubire for patient care.",

year = "2014",

doi = "10.1016/j.mmcr.2014.05.001",

language = "English (US)",

volume = "5",

pages = "16--19",

journal = "Medical Mycology Case Reports",

issn = "2211-7539",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Unmasking cryptococcal meningitis immune reconstitution inflammatory syndrome in pregnancy induced by HIV antiretroviral therapy with postpartum paradoxical exacerbation

AU - Kiggundu, Reuben

AU - Rhein, Joshua

AU - Meya, David B.

AU - Boulware, David R.

AU - Bahr, Nathan C.

N1 - Funding Information: The authors are supported by the National Institute of Neurologic Diseases and Stroke , the National Institute of Allergy and Infectious Diseases and Fogarty International Center ( R01NS086312-01 , R01AI078934-04 , R25TW009345-02 ). We thank Drs. Henry Nabeta and Abdu Musubire for patient care.

PY - 2014

Y1 - 2014

N2 - Cryptococcosis is the most common cause of meningitis in Africa due to the high burden of HIV. Immune reconstitution inflammatory syndrome (IRIS) is a frequent and deadly complication of cryptococcal meningitis. We report a fatal case of cryptococcal-IRIS in a pregnant woman that began after starting antiretroviral therapy (unmasking IRIS) and markedly worsened postpartum after delivery (paradoxical IRIS).

AB - Cryptococcosis is the most common cause of meningitis in Africa due to the high burden of HIV. Immune reconstitution inflammatory syndrome (IRIS) is a frequent and deadly complication of cryptococcal meningitis. We report a fatal case of cryptococcal-IRIS in a pregnant woman that began after starting antiretroviral therapy (unmasking IRIS) and markedly worsened postpartum after delivery (paradoxical IRIS).

KW - AIDS

KW - Cryptococcus meningitis

KW - HIV

KW - Immune reconstitution inflammatory syndrome

KW - Postpartum

KW - Pregnancy

UR - https://www.scopus.com/pages/publications/84902517737

UR - https://www.scopus.com/pages/publications/84902517737#tab=citedBy

U2 - 10.1016/j.mmcr.2014.05.001

DO - 10.1016/j.mmcr.2014.05.001

M3 - Article

C2 - 24944885

AN - SCOPUS:84902517737

SN - 2211-7539

VL - 5

SP - 16

EP - 19

JO - Medical Mycology Case Reports

JF - Medical Mycology Case Reports

IS - 1

ER -

Unmasking cryptococcal meningitis immune reconstitution inflammatory syndrome in pregnancy induced by HIV antiretroviral therapy with postpartum paradoxical exacerbation

Abstract

Bibliographical note

UN SDGs

Keywords

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