Unmasking cryptococcal meningitis immune reconstitution inflammatory syndrome in pregnancy induced by HIV antiretroviral therapy with postpartum paradoxical exacerbation

Reuben Kiggundu, Joshua Rhein, David B. Meya, David R. Boulware, Nathan C. Bahr

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Cryptococcosis is the most common cause of meningitis in Africa due to the high burden of HIV. Immune reconstitution inflammatory syndrome (IRIS) is a frequent and deadly complication of cryptococcal meningitis. We report a fatal case of cryptococcal-IRIS in a pregnant woman that began after starting antiretroviral therapy (unmasking IRIS) and markedly worsened postpartum after delivery (paradoxical IRIS).

Original languageEnglish (US)
Pages (from-to)16-19
Number of pages4
JournalMedical Mycology Case Reports
Volume5
Issue number1
DOIs
StatePublished - 2014

Bibliographical note

Funding Information:
The authors are supported by the National Institute of Neurologic Diseases and Stroke , the National Institute of Allergy and Infectious Diseases and Fogarty International Center ( R01NS086312-01 , R01AI078934-04 , R25TW009345-02 ). We thank Drs. Henry Nabeta and Abdu Musubire for patient care.

Keywords

  • AIDS
  • Cryptococcus meningitis
  • HIV
  • Immune reconstitution inflammatory syndrome
  • Postpartum
  • Pregnancy

Fingerprint Dive into the research topics of 'Unmasking cryptococcal meningitis immune reconstitution inflammatory syndrome in pregnancy induced by HIV antiretroviral therapy with postpartum paradoxical exacerbation'. Together they form a unique fingerprint.

Cite this