Unmasking cryptococcal meningitis immune reconstitution inflammatory syndrome in pregnancy induced by HIV antiretroviral therapy with postpartum paradoxical exacerbation

Reuben Kiggundu; Joshua Rhein; David B. Meya; David R. Boulware; Nathan C. Bahr

doi:10.1016/j.mmcr.2014.05.001

Unmasking cryptococcal meningitis immune reconstitution inflammatory syndrome in pregnancy induced by HIV antiretroviral therapy with postpartum paradoxical exacerbation

Reuben Kiggundu, Joshua Rhein, David B. Meya, David R. Boulware, Nathan C. Bahr

Medicine - Infectious Disease and International Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Cryptococcosis is the most common cause of meningitis in Africa due to the high burden of HIV. Immune reconstitution inflammatory syndrome (IRIS) is a frequent and deadly complication of cryptococcal meningitis. We report a fatal case of cryptococcal-IRIS in a pregnant woman that began after starting antiretroviral therapy (unmasking IRIS) and markedly worsened postpartum after delivery (paradoxical IRIS).

Original language	English (US)
Pages (from-to)	16-19
Number of pages	4
Journal	Medical Mycology Case Reports
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/j.mmcr.2014.05.001
State	Published - 2014

Bibliographical note

Funding Information:
The authors are supported by the National Institute of Neurologic Diseases and Stroke , the National Institute of Allergy and Infectious Diseases and Fogarty International Center ( R01NS086312-01 , R01AI078934-04 , R25TW009345-02 ). We thank Drs. Henry Nabeta and Abdu Musubire for patient care.

Keywords

AIDS
Cryptococcus meningitis
HIV
Immune reconstitution inflammatory syndrome
Postpartum
Pregnancy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/j.mmcr.2014.05.001

Find It

Find It at U of M Libraries

Cite this

@article{b80f34f06a2e44aebc37bd95c1496258,

title = "Unmasking cryptococcal meningitis immune reconstitution inflammatory syndrome in pregnancy induced by HIV antiretroviral therapy with postpartum paradoxical exacerbation",

abstract = "Cryptococcosis is the most common cause of meningitis in Africa due to the high burden of HIV. Immune reconstitution inflammatory syndrome (IRIS) is a frequent and deadly complication of cryptococcal meningitis. We report a fatal case of cryptococcal-IRIS in a pregnant woman that began after starting antiretroviral therapy (unmasking IRIS) and markedly worsened postpartum after delivery (paradoxical IRIS).",

keywords = "AIDS, Cryptococcus meningitis, HIV, Immune reconstitution inflammatory syndrome, Postpartum, Pregnancy",

author = "Reuben Kiggundu and Joshua Rhein and Meya, {David B.} and Boulware, {David R.} and Bahr, {Nathan C.}",

note = "Funding Information: The authors are supported by the National Institute of Neurologic Diseases and Stroke , the National Institute of Allergy and Infectious Diseases and Fogarty International Center ( R01NS086312-01 , R01AI078934-04 , R25TW009345-02 ). We thank Drs. Henry Nabeta and Abdu Musubire for patient care.",

year = "2014",

doi = "10.1016/j.mmcr.2014.05.001",

language = "English (US)",

volume = "5",

pages = "16--19",

journal = "Medical Mycology Case Reports",

issn = "2211-7539",

publisher = "Elsevier BV",

number = "1",

}

TY - JOUR

T1 - Unmasking cryptococcal meningitis immune reconstitution inflammatory syndrome in pregnancy induced by HIV antiretroviral therapy with postpartum paradoxical exacerbation

AU - Kiggundu, Reuben

AU - Rhein, Joshua

AU - Meya, David B.

AU - Boulware, David R.

AU - Bahr, Nathan C.

N1 - Funding Information: The authors are supported by the National Institute of Neurologic Diseases and Stroke , the National Institute of Allergy and Infectious Diseases and Fogarty International Center ( R01NS086312-01 , R01AI078934-04 , R25TW009345-02 ). We thank Drs. Henry Nabeta and Abdu Musubire for patient care.

PY - 2014

Y1 - 2014

N2 - Cryptococcosis is the most common cause of meningitis in Africa due to the high burden of HIV. Immune reconstitution inflammatory syndrome (IRIS) is a frequent and deadly complication of cryptococcal meningitis. We report a fatal case of cryptococcal-IRIS in a pregnant woman that began after starting antiretroviral therapy (unmasking IRIS) and markedly worsened postpartum after delivery (paradoxical IRIS).

AB - Cryptococcosis is the most common cause of meningitis in Africa due to the high burden of HIV. Immune reconstitution inflammatory syndrome (IRIS) is a frequent and deadly complication of cryptococcal meningitis. We report a fatal case of cryptococcal-IRIS in a pregnant woman that began after starting antiretroviral therapy (unmasking IRIS) and markedly worsened postpartum after delivery (paradoxical IRIS).

KW - AIDS

KW - Cryptococcus meningitis

KW - HIV

KW - Immune reconstitution inflammatory syndrome

KW - Postpartum

KW - Pregnancy

UR - http://www.scopus.com/inward/record.url?scp=84902517737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902517737&partnerID=8YFLogxK

U2 - 10.1016/j.mmcr.2014.05.001

DO - 10.1016/j.mmcr.2014.05.001

M3 - Article

C2 - 24944885

AN - SCOPUS:84902517737

SN - 2211-7539

VL - 5

SP - 16

EP - 19

JO - Medical Mycology Case Reports

JF - Medical Mycology Case Reports

IS - 1

ER -

Unmasking cryptococcal meningitis immune reconstitution inflammatory syndrome in pregnancy induced by HIV antiretroviral therapy with postpartum paradoxical exacerbation

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this