Unleashing CAR T cells to delay metabolic aging

Jenna M. Bartley; Ming Xu

doi:10.1038/s43587-024-00576-5

Unleashing CAR T cells to delay metabolic aging

Jenna M. Bartley
, Ming Xu

Research output: Contribution to journal › Comment/debate › peer-review

3 Scopus citations

Abstract

Amor and colleagues previously developed chimeric antigen receptor (CAR) T cells that can target and eliminate senescent cells. The utility of these senolytic CAR T cells is now expanded to show that they can combat age-related metabolic dysfunction, and that they can be used prophylactically and have effects that persist for months, thus opening the door to the development of long-term senolytic approaches.

Original language	English (US)
Pages (from-to)	284-286
Number of pages	3
Journal	Nature Aging
Volume	4
Issue number	3
DOIs	https://doi.org/10.1038/s43587-024-00576-5
State	Published - Mar 2024
Externally published	Yes

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Publisher Copyright:
© Springer Nature America, Inc. 2024.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/s43587-024-00576-5

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abstract = "Amor and colleagues previously developed chimeric antigen receptor (CAR) T cells that can target and eliminate senescent cells. The utility of these senolytic CAR T cells is now expanded to show that they can combat age-related metabolic dysfunction, and that they can be used prophylactically and have effects that persist for months, thus opening the door to the development of long-term senolytic approaches.",

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AU - Xu, Ming

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AB - Amor and colleagues previously developed chimeric antigen receptor (CAR) T cells that can target and eliminate senescent cells. The utility of these senolytic CAR T cells is now expanded to show that they can combat age-related metabolic dysfunction, and that they can be used prophylactically and have effects that persist for months, thus opening the door to the development of long-term senolytic approaches.

UR - https://www.scopus.com/pages/publications/85185319428

UR - https://www.scopus.com/pages/publications/85185319428#tab=citedBy

U2 - 10.1038/s43587-024-00576-5

DO - 10.1038/s43587-024-00576-5

M3 - Comment/debate

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JO - Nature Aging

JF - Nature Aging

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ER -

Unleashing CAR T cells to delay metabolic aging

Abstract

Bibliographical note

UN SDGs

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