Universal labeling of 5′-triphosphate RNAs by artificial RNA ligase enzyme with broad substrate specificity

John C. Haugner, Burckhard Seelig

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

An artificial RNA ligase specific to RNA with a 5′-triphosphate (PPP-RNA) exhibits broad sequence specificity on model substrates and secondary siRNAs with direct applications in the identification of PPP-RNAs through sequencing.

Original languageEnglish (US)
Pages (from-to)7322-7324
Number of pages3
JournalChemical Communications
Volume49
Issue number66
DOIs
StatePublished - Jul 23 2013

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