Unique profile of adenoid cystic carcinoma: A triple negative breast tumor with paradoxical features, a case report and review of literature

Dana Jaggessarsingh, Talia M. Muram-Zborovski, Lynne Bemis, William A. Robinson, Christina Finlayson, Meenakshi Singh

Research output: Contribution to journalArticle

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Adenoid cystic carcinomas (ACC) of the breast are uncommon tumors that are not well characterized and have seemingly paradoxical features. We report the case of a deceptively well circumscribed adenoid cystic carcinoma with multiple additional foci of invasive tumor. Immunohistochemical studies revealed an estrogen receptor (ER), progesterone receptor (PR), Human epidermal growth factor Receptor 2 (HER2/neu) negative tumor (triple negative tumor) with immunoreactivity for p63 and, CD 117 (c-kit). p53 was not over expressed. Gene studies did not reveal mutations in the commonly mutated exons of the TP53 and KIT genes. The unique and paradoxical features of this tumor are presented along with a review of the literature.

Original languageEnglish (US)
Pages (from-to)713-717
Number of pages5
JournalLaboratory medicine
Issue number12
StatePublished - Dec 1 2010



  • Adenoid cystic carcinoma
  • Immunohistochemistry
  • Molecular profile
  • Triple negative breast carcinoma

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