Unfolding the role of stress response signaling in endocrine resistant breast cancers

Robert Clarke, Katherine L. Cook

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


The unfolded protein response (UPR) is an ancient stress response that enables a cell to manage the energetic stress that accompanies protein folding. There has been a significant recent increase in our understanding of the UPR, how it integrates physiological processes within cells, and how this integration can affect cancer cells and cell fate decisions. Recent publications have highlighted the role of UPR signaling components on mediating various cell survival pathways, cellular metabolism and bioenergenics, and autophagy. We address the role of UPR on mediating endocrine therapy resistance and estrogen receptor-positive breast cancer cell survival.

Original languageEnglish (US)
Article number140
JournalFrontiers in Oncology
Issue numberJUN
StatePublished - 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Clarke and Cook.


  • Antiestrogen resistant breast cancer
  • Estrogen receptor-α
  • Glucose regulated protein 78
  • ICI 182,780
  • Tamoxifen
  • Unfolded protein response
  • X-box binding protein 1


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