Understanding micro-droplet interface bilayers for developing bioinspired sensors

Guru Venkatesan, Andy Sarles

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Droplet-based biomolecular arrays form the basis for a new class of bioinspired material system, whereby decreasing the sizes of the droplets and increasing the number of droplets can lead to higher functional density for the array. In this paper, we report on a non-microfluidic approach to form and connect nanoliter-to-femtoliter, lipid-coated aqueous droplets in oil to form micro-droplet interface bilayers (μDIBs). Two different modes of operation are reported for dispensing a wide range of droplet sizes (2-200μm radius). Due to the high surface-area-to-volume ratios of microdroplets at these length scales, droplet shrinking is prominent, which affects the stability and lifetime of the bilayer. To better quantify these effects, we measure the shrinkage rates for 8 different water droplet/oil compositions and study the effect of lipid placement and lipid type on morphological changes to μDIBs.

Original languageEnglish (US)
Title of host publicationMechanics and Behavior of Active Materials; Structural Health Monitoring; Bioinspired Smart Materials and Systems; Energy Harvesting
PublisherAmerican Society of Mechanical Engineers
ISBN (Print)9780791856048
DOIs
StatePublished - Jan 1 2013
EventASME 2013 Conference on Smart Materials, Adaptive Structures and Intelligent Systems, SMASIS 2013 - Snowbird, UT, United States
Duration: Sep 16 2013Sep 18 2013

Publication series

NameASME 2013 Conference on Smart Materials, Adaptive Structures and Intelligent Systems, SMASIS 2013
Volume2

Other

OtherASME 2013 Conference on Smart Materials, Adaptive Structures and Intelligent Systems, SMASIS 2013
CountryUnited States
CitySnowbird, UT
Period9/16/139/18/13

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