Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers

Missak Haigentz; Carlos Suarez; Primoz Strojan; Juan P. Rodrigo; Alessandra Rinaldo; Carol R. Bradford; June Corry; Robert P. Takes; Alfio Ferlito

doi:10.1007/s12325-018-0682-4

Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers

Missak Haigentz
, Carlos Suarez
, Primoz Strojan
, Juan P. Rodrigo
, Alessandra Rinaldo
, Carol R. Bradford
, June Corry
, Robert P. Takes
, Alfio Ferlito

Research output: Contribution to journal › Comment/debate › peer-review

18 Scopus citations

Abstract

The new 8th edition AJCC/UICC staging system for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC), developed to account for improved survival outcomes over HPV-negative cancers, includes anatomic features strictly associated with tumor-node-metastasis (TNM) and does not account for patient-specific characteristics that may impact prognosis. This commentary evaluates the evidence of smoking as an adverse prognostic factor in HPV-associated OPSCC. We review the multifactorial biological, clinical, and social/behavioral characteristics of smokers with OPSCC that impact outcomes, discuss current challenges with incorporating smoking history in prognostic classifications, and consider opportunities for future investigation.

Original language	English (US)
Pages (from-to)	255-260
Number of pages	6
Journal	Advances in Therapy
Volume	35
Issue number	3
DOIs	https://doi.org/10.1007/s12325-018-0682-4
State	Published - Mar 1 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018, Springer Healthcare Ltd., part of Springer Nature.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Head and neck cancer
HPV
Oncology
Oropharyngeal cancer
Smoking
Squamous cell carcinoma
Staging system
Survival outcomes
Tobacco carcinogens

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10.1007/s12325-018-0682-4

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title = "Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers",

abstract = "The new 8th edition AJCC/UICC staging system for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC), developed to account for improved survival outcomes over HPV-negative cancers, includes anatomic features strictly associated with tumor-node-metastasis (TNM) and does not account for patient-specific characteristics that may impact prognosis. This commentary evaluates the evidence of smoking as an adverse prognostic factor in HPV-associated OPSCC. We review the multifactorial biological, clinical, and social/behavioral characteristics of smokers with OPSCC that impact outcomes, discuss current challenges with incorporating smoking history in prognostic classifications, and consider opportunities for future investigation.",

keywords = "Head and neck cancer, HPV, Oncology, Oropharyngeal cancer, Smoking, Squamous cell carcinoma, Staging system, Survival outcomes, Tobacco carcinogens",

author = "Missak Haigentz and Carlos Suarez and Primoz Strojan and Rodrigo, \{Juan P.\} and Alessandra Rinaldo and Bradford, \{Carol R.\} and June Corry and Takes, \{Robert P.\} and Alfio Ferlito",

note = "Publisher Copyright: {\textcopyright} 2018, Springer Healthcare Ltd., part of Springer Nature.",

year = "2018",

month = mar,

day = "1",

doi = "10.1007/s12325-018-0682-4",

language = "English (US)",

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T1 - Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers

AU - Haigentz, Missak

AU - Suarez, Carlos

AU - Strojan, Primoz

AU - Rodrigo, Juan P.

AU - Rinaldo, Alessandra

AU - Bradford, Carol R.

AU - Corry, June

AU - Takes, Robert P.

AU - Ferlito, Alfio

PY - 2018/3/1

Y1 - 2018/3/1

N2 - The new 8th edition AJCC/UICC staging system for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC), developed to account for improved survival outcomes over HPV-negative cancers, includes anatomic features strictly associated with tumor-node-metastasis (TNM) and does not account for patient-specific characteristics that may impact prognosis. This commentary evaluates the evidence of smoking as an adverse prognostic factor in HPV-associated OPSCC. We review the multifactorial biological, clinical, and social/behavioral characteristics of smokers with OPSCC that impact outcomes, discuss current challenges with incorporating smoking history in prognostic classifications, and consider opportunities for future investigation.

AB - The new 8th edition AJCC/UICC staging system for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC), developed to account for improved survival outcomes over HPV-negative cancers, includes anatomic features strictly associated with tumor-node-metastasis (TNM) and does not account for patient-specific characteristics that may impact prognosis. This commentary evaluates the evidence of smoking as an adverse prognostic factor in HPV-associated OPSCC. We review the multifactorial biological, clinical, and social/behavioral characteristics of smokers with OPSCC that impact outcomes, discuss current challenges with incorporating smoking history in prognostic classifications, and consider opportunities for future investigation.

KW - Head and neck cancer

KW - HPV

KW - Oncology

KW - Oropharyngeal cancer

KW - Smoking

KW - Squamous cell carcinoma

KW - Staging system

KW - Survival outcomes

KW - Tobacco carcinogens

UR - https://www.scopus.com/pages/publications/85044276096

UR - https://www.scopus.com/pages/publications/85044276096#tab=citedBy

U2 - 10.1007/s12325-018-0682-4

DO - 10.1007/s12325-018-0682-4

M3 - Comment/debate

C2 - 29511982

AN - SCOPUS:85044276096

SN - 0741-238X

VL - 35

SP - 255

EP - 260

JO - Advances in Therapy

JF - Advances in Therapy

IS - 3

ER -

Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers

Abstract

Bibliographical note

UN SDGs

Keywords

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