Understanding behavioral effects of early life stress using the reactive scope and allostatic load models

Brittany R. Howell, Mar M. Sanchez

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The mechanisms through which early life stress leads to psychopathology are thought to involve allostatic load, the 'wear and tear' an organism is subjected to as a consequence of sustained elevated levels of glucocorticoids caused by repeated/prolonged stress activations. The allostatic load model described this phenomenon, but has been criticized as inadequate to explain alterations associated with early adverse experience in some systems, including behavior, which cannot be entirely explained from an energy balance perspective. The reactive scope model has been more recently proposed and focuses less on energy balance and more on dynamic ranges of physiological and behavioral mediators. In this review we examine the mechanisms underlying the behavioral consequences of early life stress in the context of both these models. We focus on adverse experiences that involve mother - infant relationship disruption, and dissect those mechanisms involving maternal care as a regulator of development of neural circuits that control emotional and social behaviors in the offspring. We also discuss the evolutionary purpose of the plasticity in behavioral development, which has a clear adaptive value in a changing environment.

Original languageEnglish (US)
Pages (from-to)1001-1016
Number of pages16
JournalDevelopment and psychopathology
Volume23
Issue number4
DOIs
StatePublished - Nov 2011

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