Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's disease: A review of the literature

Amit Chopra, Susannah J. Tye, Kendall H. Lee, Shirlene Sampson, Joseph Matsumoto, Andrea Adams, Bryan Klassen, Matt Stead, Julie A. Fields, Mark A. Frye

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations

Abstract

Deep brain stimulation (DBS) is a novel and effective surgical intervention for refractory Parkinson's disease (PD). The authors review the current literature to identify the clinical correlates associated with subthalamic nucleus (STN) DBS-induced hypomania/mania in PD patients. Ventromedial electrode placement has been most consistently implicated in the induction of STN DBS-induced mania. There is some evidence of symptom amelioration when electrode placement is switched to a more dorsolateral contact. Additional clinical correlates may include unipolar stimulation, higher voltage (>3 V), male sex, and/or early-onset PD. STN DBS-induced psychiatric adverse events emphasize the need for comprehensive psychiatric presurgical evaluation and follow-up in PD patients. Animal studies and prospective clinical research, combined with advanced neuroimaging techniques, are needed to identify clinical correlates and underlying neurobiological mechanisms of STN DBS-induced mania. Such working models would serve to furtherour understanding of the neurobiological underpinnings of mania and contribute valuable new insight toward development of future DBS mood-stabilization therapies.

Original languageEnglish (US)
Pages (from-to)102-110
Number of pages9
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume24
Issue number1
DOIs
StatePublished - 2012

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