Uncovering hidden in vivo resonances using editing based on localized TOCSY

Research output: Contribution to journalArticle

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Abstract

A novel single-shot spectral editing technique for in vivo proton NMR is proposed to recover resonances of low-concentration metabolites obscured by very strong resonances. With this new method, editing is performed by transferring transverse magnetization to J-coupled spins from selected coupling partners using a homonuclear Hartmann-Hahn polarization transfer with adiabatic pulses. The current implementation uses 1D-TOCSY with single-voxel localization based on LASER to recover the H1 proton of β-glucose at 4.63 ppm from under water and the lactate methyl resonances from beneath a strong lipid signal. The method can be extended to further spin systems where conventional editing methods are difficult to perform.

Original languageEnglish (US)
Pages (from-to)783-789
Number of pages7
JournalMagnetic resonance in medicine
Volume53
Issue number4
DOIs
StatePublished - Apr 2005

Keywords

  • Adiabatic pulses
  • Editing
  • Glucose
  • Lactate
  • Spectroscopy
  • TOCSY

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