Unconjugated hyperbilirubinemia and early childhood caries in a diverse group of neonates

Sanjiv B. Amin, Jeffrey M. Karp, Layne P. Benzley

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated if the development of early childhood caries is associated with the severity of unconjugated hyperbilirubinemia during the first 2 weeks after birth. We performed a retrospective case-control study of children less than 6 years of age seen for comprehensive dental examination by pediatric dentists years following a hospital stay in the neonatal intensive care unit. Exclusion criteria included genetic disorders, cleft palate, direct hyperbilirubinemia, and missing information on jaundice. Children with early childhood caries were compared with those without dental caries for a panel of perinatal and neonatal clinical variables. Seventy-six children met study criteria. Of 76 children, 42 children had early childhood caries, while 34 children had healthy primary dentitions. Among clinical variables, only race and peak total serum bilirubin concentration differed significantly between the two groups on bivariate analysis. On logistic regression, peak total serum bilirubin concentration was significantly associated with early childhood caries (adjusted odds ratio 1.17, 95% confidence interval 1.04 to 1.32). Neonatal unconjugated hyperbilirubinemia may be associated with early childhood caries in children.

Original languageEnglish (US)
Pages (from-to)393-397
Number of pages5
JournalAmerican Journal of Perinatology
Volume27
Issue number5
DOIs
StatePublished - 2010

Keywords

  • Dental caries
  • Dental enamel hypoplasia
  • Free bilirubin
  • Total serum bilirubin

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