Abstract
Electrophilic indole? Indoles, which are typically nucleophilic, can be made electrophilic through gold catalysis. By using an ortho-azido group to deliver a nitrene intramolecularly, an arylalkyne is converted into a gold carbene intermediate containing an indole skeleton that is highly electrophilic at the 3-position. A range of functionalized indoles is readily accessed by utilizing this strategy.
Original language | English (US) |
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Pages (from-to) | 8358-8362 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 50 |
Issue number | 36 |
DOIs | |
State | Published - Aug 29 2011 |
Externally published | Yes |
Keywords
- catalysis
- gold
- indole
- nitrenes
- umpolung