TY - JOUR
T1 - Umbilical cord blood transplantation and banking
AU - Brunstein, Claudio G.
AU - Wagner, John E.
PY - 2006
Y1 - 2006
N2 - Umbilical cord blood transplantation (UCBT) is an expanding practice for both pediatric and adult patients. Rapid availability, low risk of infectious disease transmission, lower risk of graft-versus-host disease, and lack of risk for the donor makes UCB an attractive alternative source of hematopoietic stem cells for transplantation. We review the state of the art of pediatric and adult UCBT and important aspects of UCB banking. Current strategies to improve clinical results and expand access to UCBT to a larger number of adult patients are discussed. New approaches to enhance hematopoietic recovery by the use of accessory cells or direct intra-bone marrow injection are also reviewed.
AB - Umbilical cord blood transplantation (UCBT) is an expanding practice for both pediatric and adult patients. Rapid availability, low risk of infectious disease transmission, lower risk of graft-versus-host disease, and lack of risk for the donor makes UCB an attractive alternative source of hematopoietic stem cells for transplantation. We review the state of the art of pediatric and adult UCBT and important aspects of UCB banking. Current strategies to improve clinical results and expand access to UCBT to a larger number of adult patients are discussed. New approaches to enhance hematopoietic recovery by the use of accessory cells or direct intra-bone marrow injection are also reviewed.
KW - Double unit UCB grafts
KW - Myeloablative UCB transplant
KW - Nonmyeloablative UCB transplant
KW - UCB banking standards
KW - UCB transplant
UR - http://www.scopus.com/inward/record.url?scp=32944479985&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=32944479985&partnerID=8YFLogxK
U2 - 10.1146/annurev.med.57.051804.123642
DO - 10.1146/annurev.med.57.051804.123642
M3 - Review article
C2 - 16409157
AN - SCOPUS:32944479985
SN - 0066-4219
VL - 57
SP - 403
EP - 417
JO - Annual review of medicine
JF - Annual review of medicine
ER -
