Abstract
Purpose: Human umbilical cord blood is a new source of hematopoietic stem cells. Patients and Methods: On the basis of prior laboratory investigations in an animal model and subsequent in vitro studies of human hematopoietic progenitors, umbilical cord blood was used to reconstitute hematopoiesis in a patient with Fanconi anemia in 1988. As a result of this first success, umbilical cord blood has been used in the treatment of 15 children with a variety of malignant and nonmalignant diseases, including acute and chronic leukemia, lymphoma, neuroblastoma, Fanconi anemia, aplastic anemia, Hunter syndrome, and congenital immunodeficiency. Results and Conclusions: This review summarizes the brief history and potential future applications of cord blood stem cells (CBSCs) in transplantation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 169-174 |
| Number of pages | 6 |
| Journal | Journal of pediatric hematology/oncology |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 1993 |
Keywords
- Anemia
- Hematopoiesis
- Leukemia
- Lymphoma
- Neuroblastoma
- Stem cells
- Umbilical cord blood
