Prostatic tissue from 39 patients was examined by light and electron microscopy, and adenocarcinoma was demonstrated in 25 patients, benign prostatic hyperplasia in 9, and prostatitis in 5. By utilizing ultrastructural features characteristic of each condition, carcinomatous cells and acini could be distinguished from benign prostatic hyperplasia even in well-differentiated cancers. In some sections, fine structural changes characteristic of carcinoma were noted even though histologic changes of carcinoma were not observed. These sections were cut from blocks adjacent to areas of histologic carcinoma and from benign prostatic hyperplasia.
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*Supported in part by U.S. Public Health Service grant AM-11376 and National Institutes of Health grant 69-2136.