Ultrastructure and steroid-binding studies in leiomyomatosis peritonealis disseminata

James A. Sutherland, Emery A. Wilson, Donald E. Edger, Deborah Powell

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Leiomyomatosis peritonealis disseminata (LPD) is characterized by the development of numerous leiomyomata throughout the peritoneal cavity which appear grossly malignant but histologically benign. The etiology of this disorder has been controversial. The tenth reported case of LPD is presented with ultrastructural evidence that these tumors arise from smooth muscle cells. The cytoplasmic estrogen and progesterone bindings by these tumors were ninefold and twofold greater than receptor concentrations in normal myometrium from the same patient. In addition to the steroid binding data, the strong association of this disorder with pregnancy or, as in this case, oral contraceptives suggests that the stimulus for neoplastic initiation and growth is hormonally related.

Original languageEnglish (US)
Pages (from-to)992-996
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Issue number8
StatePublished - Apr 15 1980


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