TY - JOUR
T1 - Ultrastructure and steroid-binding studies in leiomyomatosis peritonealis disseminata
AU - Sutherland, James A.
AU - Wilson, Emery A.
AU - Edger, Donald E.
AU - Powell, Deborah
PY - 1980/4/15
Y1 - 1980/4/15
N2 - Leiomyomatosis peritonealis disseminata (LPD) is characterized by the development of numerous leiomyomata throughout the peritoneal cavity which appear grossly malignant but histologically benign. The etiology of this disorder has been controversial. The tenth reported case of LPD is presented with ultrastructural evidence that these tumors arise from smooth muscle cells. The cytoplasmic estrogen and progesterone bindings by these tumors were ninefold and twofold greater than receptor concentrations in normal myometrium from the same patient. In addition to the steroid binding data, the strong association of this disorder with pregnancy or, as in this case, oral contraceptives suggests that the stimulus for neoplastic initiation and growth is hormonally related.
AB - Leiomyomatosis peritonealis disseminata (LPD) is characterized by the development of numerous leiomyomata throughout the peritoneal cavity which appear grossly malignant but histologically benign. The etiology of this disorder has been controversial. The tenth reported case of LPD is presented with ultrastructural evidence that these tumors arise from smooth muscle cells. The cytoplasmic estrogen and progesterone bindings by these tumors were ninefold and twofold greater than receptor concentrations in normal myometrium from the same patient. In addition to the steroid binding data, the strong association of this disorder with pregnancy or, as in this case, oral contraceptives suggests that the stimulus for neoplastic initiation and growth is hormonally related.
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U2 - 10.1016/0002-9378(80)90624-9
DO - 10.1016/0002-9378(80)90624-9
M3 - Article
C2 - 7369273
AN - SCOPUS:0018886481
SN - 0002-9378
VL - 136
SP - 992
EP - 996
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 8
ER -