Ultrastructural evaluation of mid‐dermal elastolysis

C. B. Harmon, W. P.D. Su, E. J. Gagne, A. F. Fransway, B. D. Zelickson

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Mid‐dermal elastolysis is a well‐defined clinical and histopathologic entity manifested by fine wrinkling of the skin and a mid‐dermal loss of elastic fibers. Ulfrastructural and hislologic studies were performed in an attempt to better define the cause of the elastolytic process. Biopsy specimens from the lesions of 3 patients with mid‐dermal elasiolysis were studied at light and electron microscopic levels. Ultrastructural evidence of normal elastic fiber engulfment by activated macrophages was observed; however, some fields also demonstrated envelopment of abnormally degenerated elastic tissue. Although there are many potential causes of this degeneration, photodistribution of the lesions suggests that ultraviolet damage is a primary inciting factor.

Original languageEnglish (US)
Pages (from-to)233-238
Number of pages6
JournalJournal of cutaneous pathology
Issue number3
StatePublished - Jun 1994
Externally publishedYes


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