A transplanted mammary carcinoma or a transplanted methylcholanthrene-induced tumor implanted subcutaneously on the animal’s back caused dilation of the sarcoplasmic reticulum and apparent protein loss in the white fibers only of the gastrocnemius muscle of C3H female mice. The changes were more pronounced in old mice. Ultrastructural changes were not observed in the red fibers of the gastrocnemius, in the heart, or in the diaphragm. These remote tumor effects correlate well with biochemical alterations in white fibers.
- Cancer host
- Sarcoplasmic reticulum