Ultrasonically induced release from nanosized polymer vesicles

Gautam D. Pangu, Kevin P. Davis, Frank S. Bates, Daniel A. Hammer

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Vesicles made from synthetic diblock copolymers, polymersomes, have great potential for targeted imaging and drug delivery. Ultrasound is gaining attention as a therapeutic tool in addition to its use in diagnostics. We report on the response of nanoscale vesicles made from PEO-b-PBD copolymers to ultrasound at 20 kHz. Leakage of a fluorescent dye from vesicle core was measured to study the permeation. Ultrasound causes significant leakage from the core above threshold intensity, suggesting that leakage is governed by acoustic cavitation. Size measurements and direct visualization of vesicles show that ultrasound does not completely rupture them into fragments but causes transient poration. The extent of leakage inversely depends on membrane thickness and directly depends on sonication time and intensity. (Figure Presented)

Original languageEnglish (US)
Pages (from-to)546-554
Number of pages9
JournalMacromolecular Bioscience
Volume10
Issue number5
DOIs
StatePublished - May 14 2010

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Keywords

  • Cavitation
  • Controlled release
  • Drug delivery systems
  • Membranes
  • Polymer vesicle
  • Ultrasound

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