Abstract
We demonstrate the feasibility of using ultra-short echo time (TE = 2 ms) magnetic resonance spectroscopic imaging (MRSI) to detect intracranial mobile lipids in the rat brain. High-performance outer volume suppression and pre-localization were demonstrated in phantoms and by the total absence of signals arising from extra-cranial lipids in MRSI spectra from control rats. The sequence performance was tested on glioma-bearing BDIX rats. Fast-relaxing lipid signals were spatially varied within a glioma during herpes simplex virus thymidine kinase-mediated gene therapy, demonstrating the potential application of this method.
Original language | English (US) |
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Pages (from-to) | 554-559 |
Number of pages | 6 |
Journal | NMR in biomedicine |
Volume | 19 |
Issue number | 5 |
DOIs | |
State | Published - Aug 2006 |
Keywords
- Lipids
- STEAM
- Short echo time
- Spectroscopic imaging