Ultra-short echo time spectroscopic imaging in rats: Implications for monitoring lipids in glioma gene therapy

Timo Liimatainen, Juhana Hakumäki, Ivan Tkáč, Olli Gröhn

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We demonstrate the feasibility of using ultra-short echo time (TE = 2 ms) magnetic resonance spectroscopic imaging (MRSI) to detect intracranial mobile lipids in the rat brain. High-performance outer volume suppression and pre-localization were demonstrated in phantoms and by the total absence of signals arising from extra-cranial lipids in MRSI spectra from control rats. The sequence performance was tested on glioma-bearing BDIX rats. Fast-relaxing lipid signals were spatially varied within a glioma during herpes simplex virus thymidine kinase-mediated gene therapy, demonstrating the potential application of this method.

Original languageEnglish (US)
Pages (from-to)554-559
Number of pages6
JournalNMR in biomedicine
Volume19
Issue number5
DOIs
StatePublished - Aug 1 2006

Keywords

  • Lipids
  • STEAM
  • Short echo time
  • Spectroscopic imaging

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