In this short review article I will summarize the path we took over the years towards increasing the spatial resolution of fMRI. To fully capitalize on the fMRI technique, a better understanding of the origin of the hemodynamic signals, and what factors are governing their spatial control is necessary. Here, I will briefly describe the studies and developments that ultimately led to our successful effort in mapping orientation columns in humans that is considered by many as the current state-of-the-art for fMRI studies.
Bibliographical noteFunding Information:
This work was supported, in part, by the NIH grants R01EB008645 , P41-RR008079 , P30 NS057091 and by the Human Connectome Project (U54 MH091657).
- Cortical layers
- High-resolution fMRI
- Orientation columns
- Vascular imaging