Abstract
We used ultra-high field (7 T) fMRI and parallel imaging to scan the superior parietal lobule (SPL) of human subjects as they mentally traversed a maze path in one of four directions (up, down, left, right). A counterbalanced design for maze presentation and a quasi-isotropic voxel (1.46 × 1.46 × 2 mm thick) collection were implemented. Fifty-one percent of single voxels in the SPL were tuned to the direction of the maze path. Tuned voxels were distributed throughout the SPL, bilaterally. A nearest neighbor analysis revealed a "honeycomb" arrangement such that voxels tuned to a particular direction tended to occur in clusters. Three-dimensional (3D) directional clusters were identified in SPL as oriented centroids traversing the cortical depth. There were 13 same-direction clusters per hemisphere containing 22 voxels per cluster, on the average; the mean nearest-neighbor, same-direction intercluster distance was 9.4 mm. These results provide a much finer detail of the directional tuning in SPL, as compared to those obtained previously at 4 T (Gourtzelidis et al. Exp Brain Res 165:273-282, 2005). The more accurate estimates of quantitative clustering parameters in 3D brain space in this study were made possible by the higher signal-to-noise and contrast-to-noise ratios afforded by the higher magnetic field of 7 T as well as the quasi-isotropic design of voxel data collection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 551-561 |
| Number of pages | 11 |
| Journal | Experimental Brain Research |
| Volume | 187 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jun 1 2008 |
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Keywords
- Directional tuning
- Parallel imaging
- Spatial cognition
- Superior parietal lobule
- Ultra-high field fMRI
Cite this
Ultra-high field parallel imaging of the superior parietal lobule during mental maze solving. / Jerde, Trenton A.; Lewis, Scott M.; Goerke, Ute; Gourtzelidis, Pavlos; Tzagarakis, Haris; Lynch, Joshua; Moeller, Steen; Van de Moortele, Pierre-Francois; Adriany, Gregor; Trangle, Jeran; Ugurbil, Kamil; Georgopoulos, Apostolos P.
In: Experimental Brain Research, Vol. 187, No. 4, 01.06.2008, p. 551-561.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ultra-high field parallel imaging of the superior parietal lobule during mental maze solving
AU - Jerde, Trenton A.
AU - Lewis, Scott M.
AU - Goerke, Ute
AU - Gourtzelidis, Pavlos
AU - Tzagarakis, Haris
AU - Lynch, Joshua
AU - Moeller, Steen
AU - Van de Moortele, Pierre-Francois
AU - Adriany, Gregor
AU - Trangle, Jeran
AU - Ugurbil, Kamil
AU - Georgopoulos, Apostolos P
PY - 2008/6/1
Y1 - 2008/6/1
N2 - We used ultra-high field (7 T) fMRI and parallel imaging to scan the superior parietal lobule (SPL) of human subjects as they mentally traversed a maze path in one of four directions (up, down, left, right). A counterbalanced design for maze presentation and a quasi-isotropic voxel (1.46 × 1.46 × 2 mm thick) collection were implemented. Fifty-one percent of single voxels in the SPL were tuned to the direction of the maze path. Tuned voxels were distributed throughout the SPL, bilaterally. A nearest neighbor analysis revealed a "honeycomb" arrangement such that voxels tuned to a particular direction tended to occur in clusters. Three-dimensional (3D) directional clusters were identified in SPL as oriented centroids traversing the cortical depth. There were 13 same-direction clusters per hemisphere containing 22 voxels per cluster, on the average; the mean nearest-neighbor, same-direction intercluster distance was 9.4 mm. These results provide a much finer detail of the directional tuning in SPL, as compared to those obtained previously at 4 T (Gourtzelidis et al. Exp Brain Res 165:273-282, 2005). The more accurate estimates of quantitative clustering parameters in 3D brain space in this study were made possible by the higher signal-to-noise and contrast-to-noise ratios afforded by the higher magnetic field of 7 T as well as the quasi-isotropic design of voxel data collection.
AB - We used ultra-high field (7 T) fMRI and parallel imaging to scan the superior parietal lobule (SPL) of human subjects as they mentally traversed a maze path in one of four directions (up, down, left, right). A counterbalanced design for maze presentation and a quasi-isotropic voxel (1.46 × 1.46 × 2 mm thick) collection were implemented. Fifty-one percent of single voxels in the SPL were tuned to the direction of the maze path. Tuned voxels were distributed throughout the SPL, bilaterally. A nearest neighbor analysis revealed a "honeycomb" arrangement such that voxels tuned to a particular direction tended to occur in clusters. Three-dimensional (3D) directional clusters were identified in SPL as oriented centroids traversing the cortical depth. There were 13 same-direction clusters per hemisphere containing 22 voxels per cluster, on the average; the mean nearest-neighbor, same-direction intercluster distance was 9.4 mm. These results provide a much finer detail of the directional tuning in SPL, as compared to those obtained previously at 4 T (Gourtzelidis et al. Exp Brain Res 165:273-282, 2005). The more accurate estimates of quantitative clustering parameters in 3D brain space in this study were made possible by the higher signal-to-noise and contrast-to-noise ratios afforded by the higher magnetic field of 7 T as well as the quasi-isotropic design of voxel data collection.
KW - Directional tuning
KW - Parallel imaging
KW - Spatial cognition
KW - Superior parietal lobule
KW - Ultra-high field fMRI
UR - http://www.scopus.com/inward/record.url?scp=44349181365&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44349181365&partnerID=8YFLogxK
U2 - 10.1007/s00221-008-1318-8
DO - 10.1007/s00221-008-1318-8
M3 - Article
C2 - 18305932
AN - SCOPUS:44349181365
VL - 187
SP - 551
EP - 561
JO - Experimental Brain Research
JF - Experimental Brain Research
SN - 0014-4819
IS - 4
ER -