Ultra-high-field MR in Prostate cancer: Feasibility and Potential

Carlijn J.A. Tenbergen, Gregory J. Metzger, Tom W.J. Scheenen

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Multiparametric MRI of the prostate at clinical magnetic field strengths (1.5/3 Tesla) has emerged as a reliable noninvasive imaging modality for identifying clinically significant cancer, enabling selective sampling of high-risk regions with MRI-targeted biopsies, and enabling minimally invasive focal treatment options. With increased sensitivity and spectral resolution, ultra-high-field (UHF) MRI (≥ 7 Tesla) holds the promise of imaging and spectroscopy of the prostate with unprecedented detail. However, exploiting the advantages of ultra-high magnetic field is challenging due to inhomogeneity of the radiofrequency field and high local specific absorption rates, raising local heating in the body as a safety concern. In this work, we review various coil designs and acquisition strategies to overcome these challenges and demonstrate the potential of UHF MRI in anatomical, functional and metabolic imaging of the prostate and pelvic lymph nodes. When difficulties with power deposition of many refocusing pulses are overcome and the full potential of metabolic spectroscopic imaging is used, UHF MR(S)I may aid in a better understanding of the development and progression of local prostate cancer. Together with large field-of-view and low-flip-angle anatomical 3D imaging, 7 T MRI can be used in its full strength to characterize different tumor stages and help explain the onset and spatial distribution of metastatic spread.

Original languageEnglish (US)
Pages (from-to)631-644
Number of pages14
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Issue number4
StatePublished - Aug 2022

Bibliographical note

Funding Information:
The work reported in this review coming from the Center for Magnetic Resonance Research (CMRR), University of Minnesota was supported by NIH grants NIBIB P41 EB027061 and NIBIB R01 EB029985.

Publisher Copyright:
© 2022, The Author(s).


  • Lymph nodes
  • Metabolic imaging
  • Prostate cancer
  • Ultra-high-field (UHF) MRI
  • mpMRI

PubMed: MeSH publication types

  • Journal Article
  • Review


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