Ultra-Flexible Giant Magnetoresistance Biosensors for Lab-on-a-Needle Biosensing

Diqing Su; Kai Wu; Karthik Srinivasan; Zohreh Nemati Porshokouh; Reza Zamani; Vinit K Chugh; Renata Saha; Rhonda Franklin; Jaime Modiano; Bethanie Stadler; Jianping Wang

doi:10.1002/admi.202201417

Ultra-Flexible Giant Magnetoresistance Biosensors for Lab-on-a-Needle Biosensing

Diqing Su, Kai Wu, Karthik Srinivasan, Zohreh Nemati Porshokouh, Reza Zamani, Vinit K Chugh, Renata Saha, Rhonda Franklin, Jaime Modiano, Bethanie Stadler, Jianping Wang

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Flexible biosensors exhibit great potential for the detection of various biomarkers with the ability to adapt to different surface textures. Here, a lab-on-a-needle biosensing platform based on ultra-flexible giant magnetoresistance (GMR) biosensors is developed. The fabricated flexible GMR sensors exhibit a MR ratio of 5.2% and a sensitivity of 0.13%/Oe in the linear region, which are comparable to their rigid counterparts. It is found that the magnetic properties of the flexible GMR sensors remain unchanged after 500 cycles of compressive and tensile stress, indicating strong robustness even when applied to a surface that is constantly in motion. The developed platform is then employed for the detection of different concentrations of canine osteosarcoma (OSCA-8) cells with a limit of detection (LOD) of 200 cells in 20 µL sample (10⁴ cells per mL), which demonstrate the ability to perform real-time, sensitive, and quantitative cell detection.

Original language	English (US)
Article number	2201417
Journal	Advanced Materials Interfaces
Volume	10
Issue number	7
DOIs	https://doi.org/10.1002/admi.202201417
State	Published - Mar 6 2023

Bibliographical note

Funding Information:
This study was financially supported by the Institute of Engineering in Medicine of the University of Minnesota through FY18 IEM Seed Grant Funding Program. This study was also financially supported by the U.S. Department of Agriculture – National Institute of Food and Agriculture (NIFA) under Award Number 2020-67021-31956. The authors acknowledge the MAF grant (D15CA-047) and the grant from the Skippy Frank Fund for Life Sciences and Translational Research. Portions of this work were conducted in the Minnesota Nano Center, which is supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network (NNCI) under Award Number ECCS-1542202. Portions of this work were carried out in the Characterization Facility, University of Minnesota, a member of the NSF-funded Materials Research Facilities Network (www.mrfn.org) via the MRSEC program.

Funding Information:
This study was financially supported by the Institute of Engineering in Medicine of the University of Minnesota through FY18 IEM Seed Grant Funding Program. This study was also financially supported by the U.S. Department of Agriculture – National Institute of Food and Agriculture (NIFA) under Award Number 2020‐67021‐31956. The authors acknowledge the MAF grant (D15CA‐047) and the grant from the Skippy Frank Fund for Life Sciences and Translational Research. Portions of this work were conducted in the Minnesota Nano Center, which is supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network (NNCI) under Award Number ECCS‐1542202. Portions of this work were carried out in the Characterization Facility, University of Minnesota, a member of the NSF‐funded Materials Research Facilities Network ( www.mrfn.org ) via the MRSEC program.

Publisher Copyright:
© 2023 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH.

Keywords

biosensor
cell detection
flexible
magnetic nanowire
magnetoresistance

MRSEC Support

MRFN

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1002/admi.202201417

Find It

Find It at U of M Libraries

Cite this

@article{122f581d6ab248bf82d7cf74e53ba713,

title = "Ultra-Flexible Giant Magnetoresistance Biosensors for Lab-on-a-Needle Biosensing",

abstract = "Flexible biosensors exhibit great potential for the detection of various biomarkers with the ability to adapt to different surface textures. Here, a lab-on-a-needle biosensing platform based on ultra-flexible giant magnetoresistance (GMR) biosensors is developed. The fabricated flexible GMR sensors exhibit a MR ratio of 5.2% and a sensitivity of 0.13%/Oe in the linear region, which are comparable to their rigid counterparts. It is found that the magnetic properties of the flexible GMR sensors remain unchanged after 500 cycles of compressive and tensile stress, indicating strong robustness even when applied to a surface that is constantly in motion. The developed platform is then employed for the detection of different concentrations of canine osteosarcoma (OSCA-8) cells with a limit of detection (LOD) of 200 cells in 20 µL sample (104 cells per mL), which demonstrate the ability to perform real-time, sensitive, and quantitative cell detection.",

keywords = "biosensor, cell detection, flexible, magnetic nanowire, magnetoresistance",

author = "Diqing Su and Kai Wu and Karthik Srinivasan and {Nemati Porshokouh}, Zohreh and Reza Zamani and Chugh, {Vinit K} and Renata Saha and Rhonda Franklin and Jaime Modiano and Bethanie Stadler and Jianping Wang",

note = "Funding Information: This study was financially supported by the Institute of Engineering in Medicine of the University of Minnesota through FY18 IEM Seed Grant Funding Program. This study was also financially supported by the U.S. Department of Agriculture – National Institute of Food and Agriculture (NIFA) under Award Number 2020-67021-31956. The authors acknowledge the MAF grant (D15CA-047) and the grant from the Skippy Frank Fund for Life Sciences and Translational Research. Portions of this work were conducted in the Minnesota Nano Center, which is supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network (NNCI) under Award Number ECCS-1542202. Portions of this work were carried out in the Characterization Facility, University of Minnesota, a member of the NSF-funded Materials Research Facilities Network (www.mrfn.org) via the MRSEC program. Funding Information: This study was financially supported by the Institute of Engineering in Medicine of the University of Minnesota through FY18 IEM Seed Grant Funding Program. This study was also financially supported by the U.S. Department of Agriculture – National Institute of Food and Agriculture (NIFA) under Award Number 2020‐67021‐31956. The authors acknowledge the MAF grant (D15CA‐047) and the grant from the Skippy Frank Fund for Life Sciences and Translational Research. Portions of this work were conducted in the Minnesota Nano Center, which is supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network (NNCI) under Award Number ECCS‐1542202. Portions of this work were carried out in the Characterization Facility, University of Minnesota, a member of the NSF‐funded Materials Research Facilities Network ( www.mrfn.org ) via the MRSEC program. Publisher Copyright: {\textcopyright} 2023 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH.",

year = "2023",

month = mar,

day = "6",

doi = "10.1002/admi.202201417",

language = "English (US)",

volume = "10",

journal = "Advanced Materials Interfaces",

issn = "2196-7350",

publisher = "John Wiley and Sons Ltd",

number = "7",

}

TY - JOUR

T1 - Ultra-Flexible Giant Magnetoresistance Biosensors for Lab-on-a-Needle Biosensing

AU - Su, Diqing

AU - Wu, Kai

AU - Srinivasan, Karthik

AU - Nemati Porshokouh, Zohreh

AU - Zamani, Reza

AU - Chugh, Vinit K

AU - Saha, Renata

AU - Franklin, Rhonda

AU - Modiano, Jaime

AU - Stadler, Bethanie

AU - Wang, Jianping

N1 - Funding Information: This study was financially supported by the Institute of Engineering in Medicine of the University of Minnesota through FY18 IEM Seed Grant Funding Program. This study was also financially supported by the U.S. Department of Agriculture – National Institute of Food and Agriculture (NIFA) under Award Number 2020-67021-31956. The authors acknowledge the MAF grant (D15CA-047) and the grant from the Skippy Frank Fund for Life Sciences and Translational Research. Portions of this work were conducted in the Minnesota Nano Center, which is supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network (NNCI) under Award Number ECCS-1542202. Portions of this work were carried out in the Characterization Facility, University of Minnesota, a member of the NSF-funded Materials Research Facilities Network (www.mrfn.org) via the MRSEC program. Funding Information: This study was financially supported by the Institute of Engineering in Medicine of the University of Minnesota through FY18 IEM Seed Grant Funding Program. This study was also financially supported by the U.S. Department of Agriculture – National Institute of Food and Agriculture (NIFA) under Award Number 2020‐67021‐31956. The authors acknowledge the MAF grant (D15CA‐047) and the grant from the Skippy Frank Fund for Life Sciences and Translational Research. Portions of this work were conducted in the Minnesota Nano Center, which is supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network (NNCI) under Award Number ECCS‐1542202. Portions of this work were carried out in the Characterization Facility, University of Minnesota, a member of the NSF‐funded Materials Research Facilities Network ( www.mrfn.org ) via the MRSEC program. Publisher Copyright: © 2023 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH.

PY - 2023/3/6

Y1 - 2023/3/6

N2 - Flexible biosensors exhibit great potential for the detection of various biomarkers with the ability to adapt to different surface textures. Here, a lab-on-a-needle biosensing platform based on ultra-flexible giant magnetoresistance (GMR) biosensors is developed. The fabricated flexible GMR sensors exhibit a MR ratio of 5.2% and a sensitivity of 0.13%/Oe in the linear region, which are comparable to their rigid counterparts. It is found that the magnetic properties of the flexible GMR sensors remain unchanged after 500 cycles of compressive and tensile stress, indicating strong robustness even when applied to a surface that is constantly in motion. The developed platform is then employed for the detection of different concentrations of canine osteosarcoma (OSCA-8) cells with a limit of detection (LOD) of 200 cells in 20 µL sample (104 cells per mL), which demonstrate the ability to perform real-time, sensitive, and quantitative cell detection.

AB - Flexible biosensors exhibit great potential for the detection of various biomarkers with the ability to adapt to different surface textures. Here, a lab-on-a-needle biosensing platform based on ultra-flexible giant magnetoresistance (GMR) biosensors is developed. The fabricated flexible GMR sensors exhibit a MR ratio of 5.2% and a sensitivity of 0.13%/Oe in the linear region, which are comparable to their rigid counterparts. It is found that the magnetic properties of the flexible GMR sensors remain unchanged after 500 cycles of compressive and tensile stress, indicating strong robustness even when applied to a surface that is constantly in motion. The developed platform is then employed for the detection of different concentrations of canine osteosarcoma (OSCA-8) cells with a limit of detection (LOD) of 200 cells in 20 µL sample (104 cells per mL), which demonstrate the ability to perform real-time, sensitive, and quantitative cell detection.

KW - biosensor

KW - cell detection

KW - flexible

KW - magnetic nanowire

KW - magnetoresistance

UR - http://www.scopus.com/inward/record.url?scp=85146298784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85146298784&partnerID=8YFLogxK

U2 - 10.1002/admi.202201417

DO - 10.1002/admi.202201417

M3 - Article

AN - SCOPUS:85146298784

SN - 2196-7350

VL - 10

JO - Advanced Materials Interfaces

JF - Advanced Materials Interfaces

IS - 7

M1 - 2201417

ER -

Ultra-Flexible Giant Magnetoresistance Biosensors for Lab-on-a-Needle Biosensing

Abstract

Bibliographical note

Keywords

MRSEC Support

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

MRSEC SEED Projects DMR-2011401

University of Minnesota Materials Research Science and Engineering Center (DMR-2011401)

MRFN

Cite this