Ubiquitin-positive astrogliopathy clinically mimicking Parkinson’s disease

Meaghan Morris; Abhay Moghekar; Haidan Guo; Olga Pletnikova; Javier Redding-Ochoa; Marilyn Albert; Susan M. Resnick; Liam Chen

doi:10.1186/s40478-022-01464-y

Ubiquitin-positive astrogliopathy clinically mimicking Parkinson’s disease

Meaghan Morris, Abhay Moghekar, Haidan Guo, Olga Pletnikova, Javier Redding-Ochoa, Marilyn Albert, Susan M. Resnick, Liam Chen

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

Several neurodegenerative pathologies can clinically mimic Parkinson’s disease, including neurodegenerative diseases with glial pathology. However, the glial aggregates are typically composed of known pathogenic proteins and are associated with prominent neuronal loss in the substantia nigra. Here we present an unusual case of a 91-year-old man with a clinical diagnosis of Parkinson’s disease, but whose autopsy findings showed a ubiquitin-positive astrogliopathy without significant neuronal loss in the substantia nigra. These glial aggregates affected the basal ganglia, cortex, and cerebellum, and were negative for tau, alpha-synuclein, TDP-43, FUS, and p62. This case is a rare example of an unknown glial neurodegenerative pathology mimicking Parkinson’s disease without significant loss of nigral dopaminergic neurons.

Original language	English (US)
Article number	164
Journal	Acta Neuropathologica Communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/s40478-022-01464-y
State	Published - Dec 2022

Bibliographical note

Funding Information:
This work was supported by the Intramural Research Program of the National Institute on Aging, National Institutes of Health, and by the Johns Hopkins Alzheimer’s Disease Research Center (P30-AG066507).

Publisher Copyright:
© 2022, The Author(s).

Keywords

Astrogliopathy
Neurodegeneration
Parkinsonism
Ubiquitin

PubMed: MeSH publication types

Case Reports
Journal Article
Research Support, N.I.H., Extramural

Publisher link

10.1186/s40478-022-01464-y

Find It

Find It at U of M Libraries

Cite this

@article{2b1c818ac0d140f186d7509593207be5,

title = "Ubiquitin-positive astrogliopathy clinically mimicking Parkinson{\textquoteright}s disease",

abstract = "Several neurodegenerative pathologies can clinically mimic Parkinson{\textquoteright}s disease, including neurodegenerative diseases with glial pathology. However, the glial aggregates are typically composed of known pathogenic proteins and are associated with prominent neuronal loss in the substantia nigra. Here we present an unusual case of a 91-year-old man with a clinical diagnosis of Parkinson{\textquoteright}s disease, but whose autopsy findings showed a ubiquitin-positive astrogliopathy without significant neuronal loss in the substantia nigra. These glial aggregates affected the basal ganglia, cortex, and cerebellum, and were negative for tau, alpha-synuclein, TDP-43, FUS, and p62. This case is a rare example of an unknown glial neurodegenerative pathology mimicking Parkinson{\textquoteright}s disease without significant loss of nigral dopaminergic neurons.",

keywords = "Astrogliopathy, Neurodegeneration, Parkinsonism, Ubiquitin",

author = "Meaghan Morris and Abhay Moghekar and Haidan Guo and Olga Pletnikova and Javier Redding-Ochoa and Marilyn Albert and Resnick, {Susan M.} and Liam Chen",

note = "Funding Information: This work was supported by the Intramural Research Program of the National Institute on Aging, National Institutes of Health, and by the Johns Hopkins Alzheimer{\textquoteright}s Disease Research Center (P30-AG066507). Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1186/s40478-022-01464-y",

language = "English (US)",

volume = "10",

journal = "Acta neuropathologica communications",

issn = "2051-5960",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - Ubiquitin-positive astrogliopathy clinically mimicking Parkinson’s disease

AU - Morris, Meaghan

AU - Moghekar, Abhay

AU - Guo, Haidan

AU - Pletnikova, Olga

AU - Redding-Ochoa, Javier

AU - Albert, Marilyn

AU - Resnick, Susan M.

AU - Chen, Liam

N1 - Funding Information: This work was supported by the Intramural Research Program of the National Institute on Aging, National Institutes of Health, and by the Johns Hopkins Alzheimer’s Disease Research Center (P30-AG066507). Publisher Copyright: © 2022, The Author(s).

PY - 2022/12

Y1 - 2022/12

N2 - Several neurodegenerative pathologies can clinically mimic Parkinson’s disease, including neurodegenerative diseases with glial pathology. However, the glial aggregates are typically composed of known pathogenic proteins and are associated with prominent neuronal loss in the substantia nigra. Here we present an unusual case of a 91-year-old man with a clinical diagnosis of Parkinson’s disease, but whose autopsy findings showed a ubiquitin-positive astrogliopathy without significant neuronal loss in the substantia nigra. These glial aggregates affected the basal ganglia, cortex, and cerebellum, and were negative for tau, alpha-synuclein, TDP-43, FUS, and p62. This case is a rare example of an unknown glial neurodegenerative pathology mimicking Parkinson’s disease without significant loss of nigral dopaminergic neurons.

AB - Several neurodegenerative pathologies can clinically mimic Parkinson’s disease, including neurodegenerative diseases with glial pathology. However, the glial aggregates are typically composed of known pathogenic proteins and are associated with prominent neuronal loss in the substantia nigra. Here we present an unusual case of a 91-year-old man with a clinical diagnosis of Parkinson’s disease, but whose autopsy findings showed a ubiquitin-positive astrogliopathy without significant neuronal loss in the substantia nigra. These glial aggregates affected the basal ganglia, cortex, and cerebellum, and were negative for tau, alpha-synuclein, TDP-43, FUS, and p62. This case is a rare example of an unknown glial neurodegenerative pathology mimicking Parkinson’s disease without significant loss of nigral dopaminergic neurons.

KW - Astrogliopathy

KW - Neurodegeneration

KW - Parkinsonism

KW - Ubiquitin

UR - http://www.scopus.com/inward/record.url?scp=85141839403&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85141839403&partnerID=8YFLogxK

U2 - 10.1186/s40478-022-01464-y

DO - 10.1186/s40478-022-01464-y

M3 - Article

C2 - 36376970

AN - SCOPUS:85141839403

SN - 2051-5960

VL - 10

JO - Acta neuropathologica communications

JF - Acta neuropathologica communications

IS - 1

M1 - 164

ER -

Ubiquitin-positive astrogliopathy clinically mimicking Parkinson’s disease

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

Publisher link

Find It

Other files and links

Fingerprint

Cite this