U500 disposable patch insulin pump: Results and discussion of a Veterans Affairs pilot study

Christopher Martin, David Perez-Molinar, Muhammad Shah, Charles Billington

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Wepresent a Veterans Affairs-sponsored pilot study of U500 concentrated insulin administered via disposable patch insulin pump (DPIP) vs twice-daily (BID) injections with an insulin pen in a case series format. We conducted a prospective, single-center, randomized, intent-to-treat pilot study. Ten participants were enrolled with poorly controlled diabetes, defined as hemoglobin A1C > 8.0 and severe insulin resistance defined as total daily dose > 200 units. Participants were randomized in a 1:1 ratio to either U500 DPIP or U500 BID insulin titration protocols for 14 weeks. A clinical pattern emerged where four participants randomized to the DPIP treatment arm were withdrawn early as the DPIP did not work well for the purpose studied. There was not a statistically significant difference in the rate of hypoglycemia between treatment arms. Based on our clinical experience and results, we argue against the general use of U500 DPIP in clinical practice.

Original languageEnglish (US)
Pages (from-to)1275-1283
Number of pages9
JournalJournal of the Endocrine Society
Issue number11
StatePublished - Nov 2018

Bibliographical note

Publisher Copyright:
© 2018 Endocrine Society.


  • Disposable insulin patch pump
  • Severe insulin resistance
  • Type 2 diabetes
  • U500


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