Tyrosine kinase activity is associated with CD44 in human neutrophils

Keith M. Skubitz, Kenneth D. Campbell, Amy P.n. Skubitz

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

CD44 appears to be involved in signal transduction, however, the mechanism of this function is unclear. Protein kinase activity was detected in neutrophils associated with CD44. Most of the protein kinase activity associated with these antigens was tyrosine kinase activity. Src family kinases lyn and hck were found to account for much of the associated tyrosine kinase activity. The data suggest that associated tyrosine kinase activity may play a role in signal transduction from CD44 in neutrophils to regulate other cell functions. Copyright (C) 1998 Federation of European Biochemical Societies.

Original languageEnglish (US)
Pages (from-to)97-100
Number of pages4
JournalFEBS Letters
Volume439
Issue number1-2
DOIs
StatePublished - Nov 13 1998

Keywords

  • CD44
  • Inflammation
  • Neutrophil
  • Phagocyte
  • Protein kinase
  • Signal transduction

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