Abstract
Type 2 diabetes mellitus (T2D) is an established risk factor for multiple cardiovascular diseases including atrial fibrillation (AF). The causal relationship between type 1 diabetes mellitus (T1D) and AF is poorly defined. T1D and AF share many underlying risk factors, but how T1D may promote AF independently of obesity and other features typical of T2D is not known. Here, we critically review the quality of the available clinical evidence specifically linking AF with the distinct characteristics of T1D and evaluate the mechanistic insights from preclinical models. We provide a conceptual overview of candidate contributing players and highlight important gaps in knowledge, unmet clinical needs, and potential therapeutic perspectives.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2644-2667 |
| Number of pages | 24 |
| Journal | Cardiovascular Research |
| Volume | 121 |
| Issue number | 17 |
| DOIs | |
| State | Published - Dec 1 2025 |
Bibliographical note
Publisher Copyright:© The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Arrhythmia
- Atrial fibrillation
- Type 1 diabetes
- Type 2 diabetes
PubMed: MeSH publication types
- Journal Article
- Review
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
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