TY - JOUR
T1 - Type 1 Diabetes in Acute Pancreatitis Consortium
T2 - From Concept to Reality
AU - Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC)
AU - Serrano, Jose
AU - Laughlin, Maren R.
AU - Bellin, Melena D.
AU - Yadav, Dhiraj
AU - Chinchilli, Vernon M.
AU - Andersen, Dana K.
AU - Greenbaum, Carla
AU - Kozarek, Richard
AU - Speake, Cate
AU - Lord, Sandra
AU - Irani, Shayan
AU - Linsley, Peter
AU - Kwok, William
AU - Lacy-Hulbert, Adam
AU - Hamerman, Jessica
AU - Bahnson, Henry
AU - Grubb, Brooke
AU - Williams, Cassandra
AU - Ackermann, Sarah
AU - Varner, Kimberly
AU - Goodarzi, Mark O.
AU - Pandol, Stephen J.
AU - Buxbaum, James
AU - Diniz, Marcio
AU - Goodman, Marc
AU - Hines, O. Joe
AU - Jeon, Christie
AU - Korc, Murray
AU - Li, Debiao
AU - Petrov, Maxim
AU - Pisegna, Joseph
AU - Van Eyk, Jennifer
AU - Vege, Santhi Swaroop
AU - Fogel, Evan
AU - Evans-Molina, Carmella
AU - Tirkes, Temel
AU - Sherman, Stuart
AU - Easler, Jeffrey
AU - Saeed, Zed
AU - Sims, Emily
AU - Oram, Richard
AU - Weedon, Michael
AU - Singh, Vikesh
AU - Trikudanathan, Guru
AU - Fife, Brian
AU - Freeman, Martin
AU - Harindhanavudhi, Tasma
AU - Moran, Antoinette
AU - Spilseth, Benjamin
AU - Hodges, James
N1 - Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.
PY - 2022/7/1
Y1 - 2022/7/1
N2 - ABSTRACT: Acute pancreatitis (AP), resulting from inflammation of the pancreas, accounts for more than 300,000 US hospital discharges per year. Although glucose intolerance has been known as a complication of severe AP, this effect was thought to be transient. Recently, cohort studies and meta-analysis of 24 published studies of 1100 patients who survived one or more episodes of AP revealed that 30% to 40% of patients developed diabetes or impaired glucose tolerance within 3 to 4 years of even a single episode of AP. The National Institute of Diabetes and Digestive and Kidney Diseases funded the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC) to undertake a prospective observational study of the occurrence of diabetes during an AP episode or subsequently, with emphasis on type 1 diabetes. Key factors for funding T1DAPC are the increasing incidence and prevalence of AP, its association with the development of type 1 diabetes and other forms of diabetes after AP, its complications, and associated health care cost. The T1DAPC structure, governance, and research objectives are described in this article. The DREAM (Diabetes RElated to Acute pancreatitis and its Mechanisms) studies to be undertaken by the T1DAPC are described in other articles in this journal's issue.
AB - ABSTRACT: Acute pancreatitis (AP), resulting from inflammation of the pancreas, accounts for more than 300,000 US hospital discharges per year. Although glucose intolerance has been known as a complication of severe AP, this effect was thought to be transient. Recently, cohort studies and meta-analysis of 24 published studies of 1100 patients who survived one or more episodes of AP revealed that 30% to 40% of patients developed diabetes or impaired glucose tolerance within 3 to 4 years of even a single episode of AP. The National Institute of Diabetes and Digestive and Kidney Diseases funded the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC) to undertake a prospective observational study of the occurrence of diabetes during an AP episode or subsequently, with emphasis on type 1 diabetes. Key factors for funding T1DAPC are the increasing incidence and prevalence of AP, its association with the development of type 1 diabetes and other forms of diabetes after AP, its complications, and associated health care cost. The T1DAPC structure, governance, and research objectives are described in this article. The DREAM (Diabetes RElated to Acute pancreatitis and its Mechanisms) studies to be undertaken by the T1DAPC are described in other articles in this journal's issue.
KW - Consortium for the Study of T1 Diabetes in Acute Pancreatitis
KW - DREAM study
KW - acute pancreatitis
KW - diabetes postpancreatitis
KW - type 1 diabetes mellitus
KW - Acute Disease
KW - Pancreatitis/epidemiology
KW - Humans
KW - Observational Studies as Topic
KW - Pancreas
KW - Diabetes Mellitus, Type 1/complications
KW - Glucose Intolerance
UR - http://www.scopus.com/inward/record.url?scp=85139571033&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85139571033&partnerID=8YFLogxK
U2 - 10.1097/mpa.0000000000002073
DO - 10.1097/mpa.0000000000002073
M3 - Article
C2 - 36206459
AN - SCOPUS:85139571033
SN - 0885-3177
VL - 51
SP - 563
EP - 567
JO - Pancreas
JF - Pancreas
IS - 6
ER -