Abstract
Background: The role and mechanism of NAADP, an endogenous Ca2+ mobilizing nucleotide, in autophagic regulation remain to be determined. Results: Activation of NAADP/TPC2 signaling induced the accumulation of autophagosomes. Conclusion: The NAADP/TPC2 signaling inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH. Significance: Development of agonists or antagonists of NAADP should provide a novel approach to specifically manipulate autophagy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 24247-24263 |
| Number of pages | 17 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 33 |
| DOIs | |
| State | Published - Aug 16 2013 |
Fingerprint
Dive into the research topics of 'Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS