Two novel glycosides from the fruits of Morinda Citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line

Guangming Liu, Ann Bode, Wei-Ya Ma, Zigang Dong, Shengmin Sang, Chi Tang Ho

Research output: Contribution to journalArticle

104 Scopus citations

Abstract

The fruit juice of Morinda citrifolia (noni), a plant originally grown in the Hawaiian and Tahitian islands, has long been used by islanders to treat diseases, including cancer. Two novel glycosides, 6-O-(β-D-glucopyranosyl)-1-O-octanoyl-β-D-glucopyranose and asperulosidic acid, extracted from the juice of noni fruits, were used to examine their effects on 12-O-tedtradecanoylphorbol-13-acetate (TPA)- and epidermal growth factor (EGF)-induced AP-1 transactivation and cell transformation in mouse epidermal JB6 cells. The results indicated that both compounds were effective in suppressing TPA- or EGF-induced cell transformation and associated AP-1 activity. TPA- or EGF-induced phosphorylation of c-Jun, but not extracellular signal-regulated kinases or p38 kinases, was also blocked by the compounds, indicating that c-Jun N-terminal kinases were critical in mediating TPA- or EGF-induced AP-1 activity and subsequent cell transformation in JB6 cells.

Original languageEnglish (US)
Pages (from-to)5749-5756
Number of pages8
JournalCancer Research
Volume61
Issue number15
StatePublished - Aug 1 2001

Fingerprint Dive into the research topics of 'Two novel glycosides from the fruits of Morinda Citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line'. Together they form a unique fingerprint.

Cite this