Two genomes are better than one: History, genetics, and biotechnological applications of fungal heterokaryons

Noah B. Strom, Kathryn E. Bushley

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Heterokaryosis is an integral part of the parasexual cycle used by predominantly asexual fungi to introduce and maintain genetic variation in populations. Research into fungal heterokaryons began in 1912 and continues to the present day. Heterokaryosis may play a role in the ability of fungi to respond to their environment, including the adaptation of arbuscular mycorrhizal fungi to different plant hosts. The parasexual cycle has enabled advances in fungal genetics, including gene mapping and tests of complementation, dominance, and vegetative compatibility in predominantly asexual fungi. Knowledge of vegetative compatibility groups has facilitated population genetic studies and enabled the design of innovative methods of biocontrol. The vegetative incompatibility response has the potential to be used as a model system to study biological aspects of some human diseases, including neurodegenerative diseases and cancer. By combining distinct traits through the formation of artificial heterokaryons, fungal strains with superior properties for antibiotic and enzyme production, fermentation, biocontrol, and bioremediation have been produced. Future biotechnological applications may include site-specific biocontrol or bioremediation and the production of novel pharmaceuticals.

Original languageEnglish (US)
Article number4
Pages (from-to)1-14
Number of pages14
JournalFungal Biology and Biotechnology
Volume3
Issue number1
DOIs
StatePublished - 2016

Bibliographical note

Funding Information:
We thank Kristyn Vanderwaal for encouraging the publication of this review and Jon Menke for his critical evaluation of the original manuscript. We thank Corby Kistler for his insights on nitrate non-utilizing mutants and vegetative compatibility groups, and for his critique of the manuscript.

Keywords

  • Biotechnology
  • Complementation
  • Heterokaryon
  • Heterosis
  • Parasexual cycle
  • Protoplast fusion
  • Vegetative compatibility groups

Fingerprint Dive into the research topics of 'Two genomes are better than one: History, genetics, and biotechnological applications of fungal heterokaryons'. Together they form a unique fingerprint.

Cite this