Two-Dimensional Liquid Chromatography: A State of the Art Tutorial

Dwight R. Stoll, Peter W. Carr

Research output: Contribution to journalArticlepeer-review

215 Scopus citations


In this tutorial, we discuss the motivations for doing two-dimensional liquid chromatography (2DLC) and describe the commonly used implementations of the method. We review important guiding principles for method development, discuss the state of the art in 2D-LC performance as measured by peak capacity, and describe example applications from different fields that we hope will inspire new users to adopt 2D-LC for their analytical problems.

Original languageEnglish (US)
Pages (from-to)519-531
Number of pages13
JournalAnalytical chemistry
Issue number1
StatePublished - Jan 3 2017


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