Twin studies of schizophrenia: From bow-and-arrow concordances to star wars Mx and functional genomics

Alastair G. Cardno, Irving I. Gottesman

Research output: Contribution to journalReview article

586 Scopus citations

Abstract

Twin studies have been vital for establishing an important genetic contribution to the etiology of schizophrenia. The five newest studies since 1995 from Europe and Japan have confirmed earlier findings. They yielded probandwise concordance rates of 41-65% in monozygotic (MZ) pairs and 0-28% in dizygotic (DZ) pairs, and heritability estimates of approximately 80-85%. Twin studies are also valuable for investigating the etiological relationships between schizophrenia and other disorders, and the genetic basis of clinical heterogeneity within schizophrenia. Studies of discordant MZ pairs provide further insights into non-inherited factors that contribute to the multifactorial etiology of this disorder. More recently, twin studies have begun to be used to directly investigate molecular genetic and epigenetic processes underlying schizophrenia. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)12-17
Number of pages6
JournalAmerican Journal of Medical Genetics, Part C: Seminars in Medical Genetics
Volume97
Issue number1
DOIs
StatePublished - 2000

Keywords

  • Epigenetic
  • Genetic modeling
  • Heritability
  • Heterogeneity
  • Spectrum

Fingerprint Dive into the research topics of 'Twin studies of schizophrenia: From bow-and-arrow concordances to star wars Mx and functional genomics'. Together they form a unique fingerprint.

  • Cite this