Twin pregnancy with a chimeric androgenetic and biparental placenta in one twin displaying placental mesenchymal dysplasia phenotype

Urvashi Surti, Lyndon M. Hill, Jeanette Dunn, Tracy L Prosen, Lori Hoffner

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Objectives: The aim was to report an unusual trizygotic pregnancy that resulted in live-born twins. The placenta of one twin had placental mesenchymal dysplasia (PMD), which resulted from a chimeric fusion of an androgenetic zygote and a normal biparental zygote. The literature review was summarized. Methods: The case was first detected by prenatal ultrasound, and was then followed by a histologic and detailed genetic investigation. The literature on PMD, complete hydatidiform moles (CHMs), and placental mosaicism and chimerism was also reviewed. Results: One placenta of a twin pregnancy was noted to be diffusely cystic and enlarged. The macroscopic and microscopic findings were consistent with the diagnosis of PMD; however, genetic findings confirmed confined placental chimerism involving a normal biparental 46,XY male conceptus and an androgenetic 46,XX complete hydatidiform mole. Conclusions: This case represents a rare placental abnormality, PMD, which may have a diverse etiology. Therefore, detailed histologic and genetic analysis were performed for an accurate diagnosis.

Original languageEnglish (US)
Pages (from-to)1048-1056
Number of pages9
JournalPrenatal Diagnosis
Volume25
Issue number11
DOIs
StatePublished - Nov 1 2005

Keywords

  • Androgenesis
  • Chimeric placenta
  • Complete hydatidiform mole
  • Dysplasia
  • Placental mesenchymal

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