Tweaking biological switches through a better understanding of bistability behavior

Anushree Chatterjee, Yiannis N. Kaznessis, Wei Shou Hu

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Many biological events are binary. The switch between mutually exclusive OFF to ON state in response to a stimulus is frequently mediated by a control circuit with a positive and/or a negative feedback. Such a system typically exhibits hysteresis with its switching ON and OFF stimulus levels dependent on the current state of the system. The system can be shown to be bistable both experimentally and mathematically. Work to synthesize such switches by combining natural or engineered components has begun to illustrate the potential of such control circuits in many areas of applications.

Original languageEnglish (US)
Pages (from-to)475-481
Number of pages7
JournalCurrent opinion in biotechnology
Issue number5
StatePublished - Oct 2008

Bibliographical note

Funding Information:
The work is supported partly by a grant from NIH (GM081888) to WSH.


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