Abstract
Tunneling nanotubes (TNTs) are actin-based cytoplasmic extensions that directly transfer cellular cargo between connected cells. Intercellular transport of signaling molecules and regulatory RNAs are an integral part of defining the tumor microenvironment and intratumoral heterogeneity. The TNT-based cellular mode of molecular signaling affects multiple cell functions including cellular reprograming, tumor evasion, and chemotherapy resistance. In this chapter we will discuss various concepts of intercellular communication in cancer via TNTs and highlight the potential role played by TNTs in cancer pathobiology.
| Original language | English (US) |
|---|---|
| Title of host publication | Intercellular Communication In Cancer |
| Publisher | Springer Netherlands |
| Pages | 201-225 |
| Number of pages | 25 |
| ISBN (Electronic) | 9789401773805 |
| ISBN (Print) | 9789401773799 |
| DOIs | |
| State | Published - Jan 1 2015 |
Bibliographical note
Publisher Copyright:© Springer Science+Business Media Dordrecht 2015.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Horizontal transfer
- Intercellular communication
- Intercellular nanotubes
- Intercellular transfer
- Long-range cellular communication
- Molecular networking
- Tumor heterogeneity
- Tumor-stroma interactions
- Tunneling nanotubes
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