Tunneling nanotubes: Intercellular conduits for direct cell-to-cell communication in cancer

Emil Lou; Subbaya Subramanian

doi:10.1007/978-94-017-7380-5_8

Tunneling nanotubes: Intercellular conduits for direct cell-to-cell communication in cancer

Emil Lou, Subbaya Subramanian

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

Tunneling nanotubes (TNTs) are actin-based cytoplasmic extensions that directly transfer cellular cargo between connected cells. Intercellular transport of signaling molecules and regulatory RNAs are an integral part of defining the tumor microenvironment and intratumoral heterogeneity. The TNT-based cellular mode of molecular signaling affects multiple cell functions including cellular reprograming, tumor evasion, and chemotherapy resistance. In this chapter we will discuss various concepts of intercellular communication in cancer via TNTs and highlight the potential role played by TNTs in cancer pathobiology.

Original language	English (US)
Title of host publication	Intercellular Communication In Cancer
Publisher	Springer Netherlands
Pages	201-225
Number of pages	25
ISBN (Electronic)	9789401773805
ISBN (Print)	9789401773799
DOIs	https://doi.org/10.1007/978-94-017-7380-5_8
State	Published - Jan 1 2015

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media Dordrecht 2015.

Keywords

Horizontal transfer
Intercellular communication
Intercellular nanotubes
Intercellular transfer
Long-range cellular communication
Molecular networking
Tumor heterogeneity
Tumor-stroma interactions
Tunneling nanotubes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-94-017-7380-5_8

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abstract = "Tunneling nanotubes (TNTs) are actin-based cytoplasmic extensions that directly transfer cellular cargo between connected cells. Intercellular transport of signaling molecules and regulatory RNAs are an integral part of defining the tumor microenvironment and intratumoral heterogeneity. The TNT-based cellular mode of molecular signaling affects multiple cell functions including cellular reprograming, tumor evasion, and chemotherapy resistance. In this chapter we will discuss various concepts of intercellular communication in cancer via TNTs and highlight the potential role played by TNTs in cancer pathobiology.",

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AU - Subramanian, Subbaya

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KW - Molecular networking

KW - Tumor heterogeneity

KW - Tumor-stroma interactions

KW - Tunneling nanotubes

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Tunneling nanotubes: Intercellular conduits for direct cell-to-cell communication in cancer

Abstract

Bibliographical note

Keywords

UN SDGs

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