Tunneling nanotubes: Intercellular conduits for direct cell-to-cell communication in cancer

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Tunneling nanotubes (TNTs) are actin-based cytoplasmic extensions that directly transfer cellular cargo between connected cells. Intercellular transport of signaling molecules and regulatory RNAs are an integral part of defining the tumor microenvironment and intratumoral heterogeneity. The TNT-based cellular mode of molecular signaling affects multiple cell functions including cellular reprograming, tumor evasion, and chemotherapy resistance. In this chapter we will discuss various concepts of intercellular communication in cancer via TNTs and highlight the potential role played by TNTs in cancer pathobiology.

Original languageEnglish (US)
Title of host publicationIntercellular Communication In Cancer
PublisherSpringer Netherlands
Pages201-225
Number of pages25
ISBN (Electronic)9789401773805
ISBN (Print)9789401773799
DOIs
StatePublished - Jan 1 2015

Keywords

  • Horizontal transfer
  • Intercellular communication
  • Intercellular nanotubes
  • Intercellular transfer
  • Long-range cellular communication
  • Molecular networking
  • Tumor heterogeneity
  • Tumor-stroma interactions
  • Tunneling nanotubes

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