Tuning the affinity of a synthetic sialic acid receptor using combinatorial chemistry

Steven Patterson, Bradley D. Smith, Richard E. Taylor

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Combinatorial libraries of carbohydrate receptors were produced by first derivatizing poly(allylamine) with the fluorescent boronic acid 1 followed by various mixtures of carboxylic acids. The libraries were screened for members that exhibited a larger response for sialic acid than glucose or fructose. The derivatized polymers appear to bind sialic acid by a cooperative mechanism.

Original languageEnglish (US)
Pages (from-to)3111-3114
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number20
DOIs
StatePublished - May 14 1998
Externally publishedYes

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