Tuning the affinity of a synthetic sialic acid receptor using combinatorial chemistry

Steven Patterson; Bradley D. Smith; Richard E. Taylor

doi:10.1016/S0040-4039(98)00514-0

Tuning the affinity of a synthetic sialic acid receptor using combinatorial chemistry

Steven Patterson, Bradley D. Smith, Richard E. Taylor

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Combinatorial libraries of carbohydrate receptors were produced by first derivatizing poly(allylamine) with the fluorescent boronic acid 1 followed by various mixtures of carboxylic acids. The libraries were screened for members that exhibited a larger response for sialic acid than glucose or fructose. The derivatized polymers appear to bind sialic acid by a cooperative mechanism.

Original language	English (US)
Pages (from-to)	3111-3114
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	20
DOIs	https://doi.org/10.1016/S0040-4039(98)00514-0
State	Published - May 14 1998
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgments. This work was supported by a Bayer Postdoctoral Fellowship and the National Science Foundation (USA).

Publisher link

10.1016/S0040-4039(98)00514-0

Find It

Find It at U of M Libraries

Cite this

@article{f8e964f9a71344b08c87d927dcc1b664,

title = "Tuning the affinity of a synthetic sialic acid receptor using combinatorial chemistry",

abstract = "Combinatorial libraries of carbohydrate receptors were produced by first derivatizing poly(allylamine) with the fluorescent boronic acid 1 followed by various mixtures of carboxylic acids. The libraries were screened for members that exhibited a larger response for sialic acid than glucose or fructose. The derivatized polymers appear to bind sialic acid by a cooperative mechanism.",

author = "Steven Patterson and Smith, {Bradley D.} and Taylor, {Richard E.}",

note = "Funding Information: Acknowledgments. This work was supported by a Bayer Postdoctoral Fellowship and the National Science Foundation (USA).",

year = "1998",

month = may,

day = "14",

doi = "10.1016/S0040-4039(98)00514-0",

language = "English (US)",

volume = "39",

pages = "3111--3114",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "20",

}

TY - JOUR

T1 - Tuning the affinity of a synthetic sialic acid receptor using combinatorial chemistry

AU - Patterson, Steven

AU - Smith, Bradley D.

AU - Taylor, Richard E.

N1 - Funding Information: Acknowledgments. This work was supported by a Bayer Postdoctoral Fellowship and the National Science Foundation (USA).

PY - 1998/5/14

Y1 - 1998/5/14

N2 - Combinatorial libraries of carbohydrate receptors were produced by first derivatizing poly(allylamine) with the fluorescent boronic acid 1 followed by various mixtures of carboxylic acids. The libraries were screened for members that exhibited a larger response for sialic acid than glucose or fructose. The derivatized polymers appear to bind sialic acid by a cooperative mechanism.

AB - Combinatorial libraries of carbohydrate receptors were produced by first derivatizing poly(allylamine) with the fluorescent boronic acid 1 followed by various mixtures of carboxylic acids. The libraries were screened for members that exhibited a larger response for sialic acid than glucose or fructose. The derivatized polymers appear to bind sialic acid by a cooperative mechanism.

UR - http://www.scopus.com/inward/record.url?scp=0032516325&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032516325&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(98)00514-0

DO - 10.1016/S0040-4039(98)00514-0

M3 - Article

AN - SCOPUS:0032516325

VL - 39

SP - 3111

EP - 3114

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 20

ER -

Tuning the affinity of a synthetic sialic acid receptor using combinatorial chemistry

Abstract

Bibliographical note

Publisher link

Find It

Other files and links

Fingerprint

Cite this