Tuning the affinity of a synthetic sialic acid receptor using combinatorial chemistry

Steven Patterson; Bradley D. Smith; Richard E. Taylor

doi:10.1016/S0040-4039(98)00514-0

Tuning the affinity of a synthetic sialic acid receptor using combinatorial chemistry

Steven Patterson, Bradley D. Smith, Richard E. Taylor

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Combinatorial libraries of carbohydrate receptors were produced by first derivatizing poly(allylamine) with the fluorescent boronic acid 1 followed by various mixtures of carboxylic acids. The libraries were screened for members that exhibited a larger response for sialic acid than glucose or fructose. The derivatized polymers appear to bind sialic acid by a cooperative mechanism.

Original language	English (US)
Pages (from-to)	3111-3114
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	20
DOIs	https://doi.org/10.1016/S0040-4039(98)00514-0
State	Published - May 14 1998
Externally published	Yes

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title = "Tuning the affinity of a synthetic sialic acid receptor using combinatorial chemistry",

abstract = "Combinatorial libraries of carbohydrate receptors were produced by first derivatizing poly(allylamine) with the fluorescent boronic acid 1 followed by various mixtures of carboxylic acids. The libraries were screened for members that exhibited a larger response for sialic acid than glucose or fructose. The derivatized polymers appear to bind sialic acid by a cooperative mechanism.",

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AB - Combinatorial libraries of carbohydrate receptors were produced by first derivatizing poly(allylamine) with the fluorescent boronic acid 1 followed by various mixtures of carboxylic acids. The libraries were screened for members that exhibited a larger response for sialic acid than glucose or fructose. The derivatized polymers appear to bind sialic acid by a cooperative mechanism.

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