Abstract
Combinatorial libraries of carbohydrate receptors were produced by first derivatizing poly(allylamine) with the fluorescent boronic acid 1 followed by various mixtures of carboxylic acids. The libraries were screened for members that exhibited a larger response for sialic acid than glucose or fructose. The derivatized polymers appear to bind sialic acid by a cooperative mechanism.
Original language | English (US) |
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Pages (from-to) | 3111-3114 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 39 |
Issue number | 20 |
DOIs | |
State | Published - May 14 1998 |
Externally published | Yes |