TY - JOUR
T1 - Tumorigenicity of 5-Methylchrysene Dihydrodiols and Dihydrodiol Epoxides in Newborn Mice and on Mouse Skin
AU - Hecht, Stephen S.
AU - Radok, Lynn
AU - Amin, Shantu
AU - Huie, Keith
AU - Melikian, Assieh A.
AU - Hoffmann, Dietrich
AU - Pataki, John
AU - Harvey, Ronald G.
PY - 1985/4/1
Y1 - 1985/4/1
N2 - 5-Methylchrysene, (±-trans-1,2-dihydro-1,2-dihydroxy-5-methylchrysene, (±-trans-7,8-dihydro-7,8-dihydroxy-5-methyl-chrysene, (±)-trans-1,2-dihydroxy-anti-3,4-epoxy-1,2,3,4-tetra-hydro-5-methylchrysene (anti-DE-l), (±trans-1,2-dihydroxy-«yr?-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (syn-DE-l), and (±trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydro-5-methylchrysene (anti-DE-ll) were tested for tumorigenicity in newborn mice and for tumor-initiating activity on mouse skin. In newborn mice, a total dose of 56 nmol of anti-DE-l induced 4.6 lung tumors/mouse and 1.2 liver tumors/mouse. These incidences were significantly higher than observed for any of the other metabolites, tested at equimolar doses. The results indicate that anti-DE-l, but not syn-DE-l or anti-DE-ll, is a major ultimate carcinogen of 5-methylchrysene in the newborn mouse. Anti-DE-l was also more tumorigenic than anti-DE-lf on mouse skin, inducing 4.4 tumors/mouse after an initiating dose of 100 nmol, compared to zero tumors per mouse induced by anti-DE-II. However, anti-DE-l was less tumorigenic on mouse skin than was its metabolic precursor, trans-1,2-dihydro-1,2-dihydroxy-5-methylchrysene or its parent hydrocarbon, 5-methylchrysene.
AB - 5-Methylchrysene, (±-trans-1,2-dihydro-1,2-dihydroxy-5-methylchrysene, (±-trans-7,8-dihydro-7,8-dihydroxy-5-methyl-chrysene, (±)-trans-1,2-dihydroxy-anti-3,4-epoxy-1,2,3,4-tetra-hydro-5-methylchrysene (anti-DE-l), (±trans-1,2-dihydroxy-«yr?-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (syn-DE-l), and (±trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydro-5-methylchrysene (anti-DE-ll) were tested for tumorigenicity in newborn mice and for tumor-initiating activity on mouse skin. In newborn mice, a total dose of 56 nmol of anti-DE-l induced 4.6 lung tumors/mouse and 1.2 liver tumors/mouse. These incidences were significantly higher than observed for any of the other metabolites, tested at equimolar doses. The results indicate that anti-DE-l, but not syn-DE-l or anti-DE-ll, is a major ultimate carcinogen of 5-methylchrysene in the newborn mouse. Anti-DE-l was also more tumorigenic than anti-DE-lf on mouse skin, inducing 4.4 tumors/mouse after an initiating dose of 100 nmol, compared to zero tumors per mouse induced by anti-DE-II. However, anti-DE-l was less tumorigenic on mouse skin than was its metabolic precursor, trans-1,2-dihydro-1,2-dihydroxy-5-methylchrysene or its parent hydrocarbon, 5-methylchrysene.
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M3 - Article
C2 - 3838497
AN - SCOPUS:0021795425
SN - 0008-5472
VL - 45
SP - 1449
EP - 1452
JO - Cancer Research
JF - Cancer Research
IS - 4
ER -
