Tumorigenicity and metabolism of 1-nitropyrene in A/J mice

Karam El-bayoumy, Stephen S. Hecht, Terri Sackl, Gary D. Stoner

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

Four groups of 28-32 male and female A/J mice were given i.p. injections of either trioctanoin or 1-nitropyrene In trioctanoin such that the total doses of 1-nitropyrene were 0.71 mmol/kg, 2.14 mmol/kg, or 6.44 mmol/kg. The mean number of lung tumors/mouse was 1.3± 1.0 in the group treated with 6.44 mmol/kg of 1-nitropyrene compared with 0.3± 0.6 in the trioctanoin group (p <0.001). Combined tumor incidence was not significant compared with controls in the two lower dose groups. Cultured explants of A/J mouse lung, and 9000 g supernatant of A/J mouse lung and liver, metabolized [14C]1-nitropyrene to 4,5-dihydro-4,5-dihydroxy-1-nitropyrene and 1-nitrohydroxypyrenes. Substantial amounts of unknown polar metabolites were also produced by cultured lung. Nitro-reduction to 1-aminopyrene was minimal in mouse lung and liver, even under oxygen deficient conditions.

Original languageEnglish (US)
Pages (from-to)1449-1452
Number of pages4
JournalCarcinogenesis
Volume5
Issue number11
DOIs
StatePublished - Nov 1984

Bibliographical note

Funding Information:
A study of Chemical Carcinogenesis, 71. We thank Elizabeth Greisiger and Merrill Babcock for technical assistance and Mrs Lori DeMarco for typing this manuscript. This work was supported by NCI Grant CA-35519 and by the U.S. Army Medical Research and Development Command.

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