Tumor-targeting glycol chitosan nanoparticles as a platform delivery carrier in cancer diagnosis and therapy

So Jin Lee, Hyun Su Min, Sook Hee Ku, Sohee Son, Ick Chan Kwon, Sun Hwa Kim, Kwangmeyung Kim

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

A natural based polymer, chitosan has received widespread attention in drug delivery systems due to its valuable physicochemical and biological characteristics. In particular, hydrophobic moiety-conjugated glycol chitosan can form amphiphilic self-assembled glycol chitosan nanoparticles (GCNPs) and simultaneously encapsulate hydrophobic drug molecules inside their hydrophobic core. This GCNP-based drug delivery systems exhibit excellent tumor-homing efficacy, attributed to the long blood circulation and the enhanced permeability and retention effect; this tumor-targeting drug delivery results in improved therapeutic efficiency. In this review, we describe the requisite properties of GCNPs for cancer therapy as well as imaging for diagnosis, such as their basic characteristics, in vitro delivery efficiency and in vivo tumor-targeting ability.

Original languageEnglish (US)
Pages (from-to)1697-1713
Number of pages17
JournalNanomedicine
Volume9
Issue number11
DOIs
StatePublished - Aug 1 2014

Keywords

  • EPR
  • amphiphilic nanoparticles
  • cancer therapy
  • diagnosis
  • glycol chitosan

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    Lee, S. J., Min, H. S., Ku, S. H., Son, S., Kwon, I. C., Kim, S. H., & Kim, K. (2014). Tumor-targeting glycol chitosan nanoparticles as a platform delivery carrier in cancer diagnosis and therapy. Nanomedicine, 9(11), 1697-1713. https://doi.org/10.2217/nnm.14.99