Tumor suppression and normal aging in mice with constitutively high p53 activity

Susan M. Mendrysa; Kathleen A. O'Leary; Matthew K. McElwee; Jennifer Michalowski; Robert N. Eisenman; Douglas A. Powell; Mary Ellen Perry

doi:10.1101/gad.1378506

Tumor suppression and normal aging in mice with constitutively high p53 activity

Susan M. Mendrysa, Kathleen A. O'Leary, Matthew K. McElwee, Jennifer Michalowski, Robert N. Eisenman, Douglas A. Powell, Mary Ellen Perry

Medicine - Rheumatic and Autoimmune

Research output: Contribution to journal › Article › peer-review

179 Scopus citations

Abstract

The p53 inhibitor murine double-minute gene 2 (Mdm2) is a target for potential cancer therapies, however increased p53 function can be lethal. To directly address whether reduced Mdm2 function can inhibit tumorigenesis without causing detrimental side effects, we exploited a hypomorphic murine allele of mdm2 to compare the effects of decreased levels of Mdm2 and hence increased p53 activity on tumorigenesis and life span in mice. Here we report that mice with decreased levels of Mdm2 are resistant to tumor formation yet do not age prematurely, supporting the notion that Mdm2 is a promising target for cancer therapeutics.

Original language	English (US)
Pages (from-to)	16-21
Number of pages	6
Journal	Genes and Development
Volume	20
Issue number	1
DOIs	https://doi.org/10.1101/gad.1378506
State	Published - Jan 1 2006

Keywords

Aging
Apoptosis
Cancer therapy
Mdm2
Tumor suppression
p53

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1101/gad.1378506

Find It

Find It at U of M Libraries

Cite this

@article{d39b4b4ca1eb4d6daf55c2243324b65e,

title = "Tumor suppression and normal aging in mice with constitutively high p53 activity",

abstract = "The p53 inhibitor murine double-minute gene 2 (Mdm2) is a target for potential cancer therapies, however increased p53 function can be lethal. To directly address whether reduced Mdm2 function can inhibit tumorigenesis without causing detrimental side effects, we exploited a hypomorphic murine allele of mdm2 to compare the effects of decreased levels of Mdm2 and hence increased p53 activity on tumorigenesis and life span in mice. Here we report that mice with decreased levels of Mdm2 are resistant to tumor formation yet do not age prematurely, supporting the notion that Mdm2 is a promising target for cancer therapeutics.",

keywords = "Aging, Apoptosis, Cancer therapy, Mdm2, Tumor suppression, p53",

author = "Mendrysa, {Susan M.} and O'Leary, {Kathleen A.} and McElwee, {Matthew K.} and Jennifer Michalowski and Eisenman, {Robert N.} and Powell, {Douglas A.} and Perry, {Mary Ellen}",

year = "2006",

month = jan,

day = "1",

doi = "10.1101/gad.1378506",

language = "English (US)",

volume = "20",

pages = "16--21",

journal = "Genes and Development",

issn = "0890-9369",

publisher = "Cold Spring Harbor Laboratory Press",

number = "1",

}

TY - JOUR

T1 - Tumor suppression and normal aging in mice with constitutively high p53 activity

AU - Mendrysa, Susan M.

AU - O'Leary, Kathleen A.

AU - McElwee, Matthew K.

AU - Michalowski, Jennifer

AU - Eisenman, Robert N.

AU - Powell, Douglas A.

AU - Perry, Mary Ellen

PY - 2006/1/1

Y1 - 2006/1/1

N2 - The p53 inhibitor murine double-minute gene 2 (Mdm2) is a target for potential cancer therapies, however increased p53 function can be lethal. To directly address whether reduced Mdm2 function can inhibit tumorigenesis without causing detrimental side effects, we exploited a hypomorphic murine allele of mdm2 to compare the effects of decreased levels of Mdm2 and hence increased p53 activity on tumorigenesis and life span in mice. Here we report that mice with decreased levels of Mdm2 are resistant to tumor formation yet do not age prematurely, supporting the notion that Mdm2 is a promising target for cancer therapeutics.

AB - The p53 inhibitor murine double-minute gene 2 (Mdm2) is a target for potential cancer therapies, however increased p53 function can be lethal. To directly address whether reduced Mdm2 function can inhibit tumorigenesis without causing detrimental side effects, we exploited a hypomorphic murine allele of mdm2 to compare the effects of decreased levels of Mdm2 and hence increased p53 activity on tumorigenesis and life span in mice. Here we report that mice with decreased levels of Mdm2 are resistant to tumor formation yet do not age prematurely, supporting the notion that Mdm2 is a promising target for cancer therapeutics.

KW - Aging

KW - Apoptosis

KW - Cancer therapy

KW - Mdm2

KW - Tumor suppression

KW - p53

UR - http://www.scopus.com/inward/record.url?scp=29944447632&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29944447632&partnerID=8YFLogxK

U2 - 10.1101/gad.1378506

DO - 10.1101/gad.1378506

M3 - Article

C2 - 16391230

AN - SCOPUS:29944447632

SN - 0890-9369

VL - 20

SP - 16

EP - 21

JO - Genes and Development

JF - Genes and Development

IS - 1

ER -

Tumor suppression and normal aging in mice with constitutively high p53 activity

Abstract

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this