Tumor necrosis factor-α increases hepatic DNA and RNA and hepatocyte mitosis

H. S. Beyer, M. Stanley, A. Theologides

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Tumor necrosis factor-α (TNF) has been reported to increase DNA synthesis in normal rat liver. Therefore, we examined the effects of TNF on rat liver regeneration. TNF, 1.5 μg ip every 4 h for 5 d, significantly increased hepatic DNA and RNA contents of regenerating and sham operated livers by up to 45%. Mitotic figures in sham operated liver, usually rare, were increased substantially by TNF. ODC mRNA content and enzyme activity were increased in regenerating liver, and were further increased by TNF. These data indicate that TNF, although not specific for regenerating liver, is a potent stimulus for hepatocyte DNA synthesis and mitosis.

Original languageEnglish (US)
Pages (from-to)405-410
Number of pages6
JournalBiochemistry International
Volume22
Issue number3
StatePublished - Dec 1 1990

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