Tumor load in patients with follicular lymphoma post stem cell transplantation may correlate with clinical course

C. C. Chang, C. Bredeson, M. Juckett, B. Logan, C. A. Keever-Taylor

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The purpose of this study was to evaluate if the tumor load, as determined by a real-time quantitative PCR (RQ-PCR) assay, correlated with the clinical course of follicular lymphoma patients after stem cell transplantation (SCT). Cryopreserved bone marrow and/or peripheral blood samples obtained at different time intervals after SCT from 11 patients (seven allogeneic, T-cell depleted/four autologous) were tested for tumor load, as defined by t(14;18) positive cells/total cells, using RQ-PCR. None of the six patients who remained in remission had samples with a tumor load >0.01% after SCT, although fluctuating tumor loads of ≤0.01% were observed in three of these patients. In contrast, four of the five patients (three allogeneic/two autologous) with relapsed/progressive disease had increasing tumor loads of > 0.01% after SCT (0/6 vs 4/5, P <0.02, Fisher's exact). Our results suggest that RQ-PCR measurable tumor load >0.01% after SCT may correlate with relapsed/progressive disease. Prospective studies with greater numbers of cases are indicated to better determine the critical tumor load that predicts poor outcome after SCT with RQ-PCR.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalBone marrow transplantation
Volume32
Issue number3
DOIs
StatePublished - Aug 2003
Externally publishedYes

Keywords

  • Clinical course
  • Follicular lymphoma
  • Quantitative PCR
  • RQ-PCR
  • Relapse
  • SCT
  • Tumor load

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